comparative pathobiology of fungal pathogens of plants and animals比较病理学真菌病原体的植物和动物.pdfVIP

Pearls Comparative Pathobiology of Fungal Pathogens of Plants and Animals Martin B. Dickman1,2, Paul de Figueiredo1,2,3,4* 1 Borlaug Advanced Research Center, Texas AM University, College Station, Texas, United States of America, 2 Department of Plant Pathology Microbiology, Texas AM University, College Station, Texas, United States of America, 3 Department of Veterinary Pathobiology, Texas AM University, College Station, Texas, United States of America, 4 Department of Microbial and Molecular Pathogenesis, Texas AM Health Science Center, College Station, Texas, United States of America Pathogenic fungi constitute a vast and diverse kingdom of plant tissue [2]. Thus, the fungus tricks the host into generating eukaryotic organisms that interact with an equally vast and nutrient-rich dead cells that are of sole and direct benefit to the diverse collection of hosts. Despite this extraordinary diversity, fungus. unrelated fungi have strikingly similar needs and interests: Fusarium spp. are rich sources of mycotoxins and other nutrient acquisition, growth, niche establishment, and reproduc- secondary metabolites. Fumonisin (FB1), for example, is a tion. To support these activities, fungi have evolved remarkably sphinganine analog and mycotoxin produced by Fusarium sophisticated mechanisms for interacting with host organisms, verticillioides, a maize endophyte associated with stalk rot disease. and modulating the speed, timing, and magnitude of these This toxin alters sphingolipid biosynthesis [3], modulates protein interactions. In the case of opportunistic human fungal kinase C activity [4,5], and also promotes disease in livestock and pathogens, these mechanisms have