以主动脉瓣膜病变为突出表现的干燥综合征1例报道.docVIP

以主动脉瓣膜病变为突出表现的干燥综合征1例报道 王留均 魏艳林 张卓莉 北京大学第一医院风湿免疫科 郑州市人民医院风湿免疫科 X 关注成功！ 加关注后您将方便地在 我的关注中得到本文献的被引频次变化的通知！ 新浪微博 腾讯微博 人人网 开心网 豆瓣网 网易微博 关键词： 干燥综合征; 主动脉瓣狭窄; 病例报告; 作者简介：张卓莉 e-mail, zhuoli.zhang@126.com 收稿日期：2016-02-19 A Sjgrens syndrome patient with prominent aortic valve involvement:a case report WANG Liu-jun WEI Yan-lin ZHANG Zhuo-li Department of Rheumatology and Clinical Immunology, Peking University First Hospital; Department of Rheumatology and Clinical Immunology, Peoples Hospital of Zhengzhou; Abstract： Sjgrens syndrome is a systemic autoimmune disease which is characterized by xerosis, and multiple organs can be affected, causing interstitial lung disease, renal tubular acidosis, blood system involvement, peripheral neuropathy, and liver damage, but cardiac involvement is rare. Here we report a case of Sjgrens syndrome with prominent aortic valve involvement. A 66-year-old woman was admitted for exertional dyspnea, and the ultrasonic cardiogram showed severe aortic stenosis with moderate regurgitation. Preoperative examination for valve replacement found that the patient had elevated erythrocyte sedimentation rate and positive rheumatoid factor, so she was referred to the rheumatology outpatient department for further examination and treatment. Further questions about medical history found that the patient had dry eyes and dry mouth for more than ten years, and had obvious caries. Further laboratory examination showed elevated serum immunoglobulin levels and positive anti-nuclear antibody. The findings of ophthalmologic examination and labial gland biopsy also supported the diagnosis of Sj9 gren s syndrome. After treatment of glucocorticoids and hydroxychloroquine for ten months, her dyspnea symptoms were obviously improved in the patient, and the rheumatoid factor had become negative while her erythrocyte sedimentation rate normal. Repeated ultrasonic cardiogram examination showed that her aortic stenosis was also improved. The patient has been