预处理对黄连解毒汤综合模拟体系陶瓷膜微滤过程的研究.pdfVIP

中草药 Chinese Traditional and Herbal Drugs 第 44 卷 第 22 期 2013 年 11 月 ·3147 · 预处理对黄连解毒汤综合模拟体系陶瓷膜微滤过程的研究 1 1, 2 1* 1 李 博 ，张连军 ，郭立玮 ，付廷明 1. 南京中医药大学 中药复方分离工程重点实验室，江苏 南京 210029 2. 江苏省荣军医院，江苏 无锡 214035 摘 要：目的 优化中药水提液膜分离前的预处理方式。方法 以黄连解毒汤水提液中4 种共性高分子物质和小分子药效物 质（小檗碱、栀子苷）组成的综合模拟体系为研究对象，通过不同预处理方式调节溶液环境，分别考察不同溶液环境对膜通 量、共性高分子物质去除率、小分子药效物质透过率等指标的影响。结果 调节 pH 值对膜通量的改善较为明显，共性高分 子物质截留率较高；调节 pH 值和离子强度（加入 0.05 mol/L NaCl ）时小分子药效物质透过率相对理想。研究发现，膜堵塞 阻力是膜污染的主要因素。结论 综合各项指标，黄连解毒汤以调节离子强度和调节 pH 值为 6.5 时的预处理效果较为理想； 对于中药水提液的膜分离前预处理具有一定的参考意义。 关键词：无机陶瓷膜；预处理；模拟体系；共性高分子；阻力分布 中图分类号：R284.2 文献标志码：A 文章编号：0253 - 2670(2013)22 - 3147 - 07 DOI: 10.7501/j.issn.0253-2670.2013.22.011 Pretreatments on microfiltration with ceramic membranes for comprehensive simulation system of Huanglian Jiedu Decoction 1 1, 2 1 1 LI Bo , ZHANG Lian-jun , GUO Li-wei , FU Ting-ming 1. Key Laboratory of Separation Engineering for Chinese Medicine Compound, Nanjing University of Chinese Medicine, Nanjing 210029, China 2. Jiangsu Provincial Rongjun Hospital, Wuxi 214035, China Abstract: Objective To optimize the pretreatment on the water extract of Chinese materia medica (CMM) before membrane separation. Methods Using the comprehensive simulation system of four common polymers and index components existed in the water extract of CMM (berberine and geniposide) as the research object, the solution environment was adjusted by different pretreatments. The flux of microfiltration, transmittance of the ingredients, and removal rate of common polymers were selected as indicators to study the effects of different solution environments. Results It was found that adjusting pH could change the permeation flux obviously, and the rem