中医药干预神经病理性疼痛的作用机制研究进展.docVIP

中医药干预神经病理性疼痛的作用机制研究进展 郭秋岩 张彦琼 林娜 中国中医科学院中药研究所 X 关注成功！ 加关注后您将方便地在 我的关注中得到本文献的被引频次变化的通知！ 新浪微博 腾讯微博 人人网 开心网 豆瓣网 网易微博 摘????要： 神经病理性疼痛是一种发病机制复杂的难治性疾病, 目前主要的治疗手段是药物干预.由于西药存在镇痛作用有限、副作用明显、价格昂贵等局限性, 越来越多的神经病理性疼痛患者试图寻求中医药手段缓解症状, 改善病情和提高生命、生活质量.中医注重在整体观和辨证论治思想的指导下用药, 对患者进行整体调理.中药具有多成分、多靶点、多途径发挥作用的特点, 在治疗神经病理性疼痛方面具有独特的优势.本综述通过分别在中国知网和Pubmed数据库检索近年来中医药治疗神经病理性疼痛的文献报道, 总结中医药治疗神经病理性疼痛的理论基础, 汇总中药单体 (包括植物药、动物药和矿物药) 、中药复方和中医非药物手段治疗神经病理性疼痛的作用机制, 为神经病理性疼痛的临床安全、合理用药及新药研发提供参考依据. 关键词： 神经病理性疼痛; 中药单体; 中药复方; 作用机制; 作者简介：郭秋岩 研究方向:中药药理.E-mail:reborn528866@126.com 作者简介：张彦琼 博士, 副研究员.研究方向:中医药系统生物学.E-mail:yqzhang@ 作者简介：林娜 博士, 研究员.研究方向:中药药理学.E-mail:linna888@163.com 收稿日期：2017-05-05 基金：北京市科技新星项目 (Z1511000003150126) Research progress on the pharmacological mechanisms of traditional Chinese medicine in the treatment of neuropathic pain GUO QIU-Yan ZHANG Yan-Qiong LIN Na Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences; Abstract： Neuropathic pain ( NP) is one of the most difficult types of chronic pain to manage with its complex pathogenesis.Due to the unsatisfied analgesic effects, obvious side effects and high price, an increasing number of NP patients are trying to seek traditional Chinese medicine ( TCM) to relieve symptoms, ameliorate the condition of health and improve the quality of life. Under the guidance of holistic view and dialectical theory, TCM is characterized by multiple components, multiple targets and holistic regulation, and has been widely utilized in clinics for centuries. In this review, we collected published papers on the pharmacological mechanisms of TCM in the treatment of NP from CNKI and Pub Med. By literature analysis, we concluded mechanisms of monomer of TCM which include plants, animals and mineral drugs, Chinese formulae and non-drug methods of TCM in the treatment of NP, so as to provide reference for rational administration and drug development. Keyword： neuropathic pain; monomer of traditional Chinese medicine; Chinese for