卵巢上皮性癌复发规律的探讨.docVIP

卵巢上皮性癌复发规律的探讨 癌症 2000年第6期第19卷 临床研究 作者：李艳芳　李孟达　李俊东　刘富元　刘继红 单位：李艳芳　李孟达　李俊东　刘富元　刘继红（中山医科大学肿瘤防治中心妇科，广东广州510060） 关键词：卵巢肿瘤；复发；药物疗法 　　【摘要】目的：了解卵巢上皮性癌的复发规律，探讨降低复发率的可能措施。方法：回顾性分析1985年1月至1994年12月在我院经细胞减灭术后肿瘤残留灶≤2cm的卵巢上皮癌Ⅰ～Ⅲ期189例临床资料，其中Ⅰ期81例、Ⅱ期19例、Ⅲ期89例。97例术后按计划完成铂类药物为主的化疗。结果：189例中70例复发，总的复发率为37.0％。1年以内、2年以内、3年以内和5年以上的复发患者各占41.4％、65.7％、74.3％和8.6％。Ⅰ期和Ⅱ、Ⅲ期的复发率分别为12.3％和55.6％（P＜0.01）。完成化疗计划者和未完成者的复发率分别为27.6％和 　　46.7％（P＜0.01）。对年龄、病理类型、手术分期和术后化疗四个因素进行多因素Logistic回归分析表明，手术分期和化疗是影响复发的显著性因素（P分别＜0.01和0.05）。结论：卵巢上皮性癌术后复发大多在3年之内。复发率与手术分期及术后化疗密切相关。早期诊断和术后有计划的化疗可望减少复发，改善预后。 　　中图分类号：R737.31　文献标识码：A 　　文章编号：1000－467X（2000）06－0600－03 Study of recurrent characteristics of epithelial ovarian carcinoma LI Yan-fang, LI Meng-da, LI Jun-dong, et al. 　　Department of Gynecologic Oncology, Cancer Center, Sun Yat-sen University 　　of Medical Sciences, Guangzhou 510060, P.R.China 　　【 Abstract】 Objective:To investigate the recurrent characterstics of epithelial ovarian cancer and study the possible method to reduce recurrence. Method: The clinical data of 189 cases of stage Ⅰ ～ Ⅲ epithelial ovarian carcinoma patients(stage Ⅰ 81cases,stage Ⅱ 19,and stage Ⅲ 89) who were admitted to our hospital during Jan 1, 1985 to Dec 31, 1994 and received optimal surgery (residual≤ 2 cm) were analyzed retrospectively.Ninty-seven cases have finished post operative chemotherapy plan. Seventy out of 189 cases relapsed. Results: The overall recurrent rate was 37.0％ and the recurrency of ≤ 1 year post-operation,≤ 2 years,≤ 3 years and ＞5 years was 41.1％ , 65.7％ ,74.3％ and 8.6％ ,respectively. Twelve point three percent of stage I patients relapsed and 55.6％ in stage Ⅱ , Ⅲ (P＜ 0.01). The recurrent rate of those who have finished post-operative chemotherapy and those who haven#039;t was 27.6％ and 46.7％ respectively (P＜ 0.01).Multivariate Logistic regression with age, pathological type, stage and post-operative chemotherapy showed that stage and chemotherapy were the significant factors for recurrence (P＜ 0.01 and P＜ 0.05). Conclu