不同负荷运动对大鼠脑衰老及学习记忆能力影响-effect of different loads of exercise on brain aging and learning and memory ability in rats.docxVIP

LPO collected from cerebral cortex and hippocamps of rats would be measured with the biochemistry method.Ultrastructures of tissues were observed with electron microscope.Results:change in morphology :cristae on cerebral Mitochondria partly solvated with membrane;granules and degranulations on rough endoplasmic reticulum dissolved ; part of nuclear membrane became irregular in the shape. The amount of hippocampus organelles and chromatin lessened, cytoplasm and mitochondria edema.Cerebra nucleus of group Ss rats are ellipse, and they have rich cytoplasm and less heterochromatin.In eight-arm maze task,the error times are increasing orderly from Group C ,Group S and Group M.The error times is greater for rats in Group M than those in Group C and rats in Group S and Group B can seek food correctly than those in Group M in unit time.Compared with rats in Group C, the amount of MDA and LPO in cerebral cortex and hippocampus of those in Group M is increasing but the activity of SOD and GSH-Px is decreasing.Compared with Group M, the activity of SOD and GSH-Px for rats in Group S is increasing, while the amount of MDA in cerebral cortex and hippocampus is decreasing.Conelusion:Within a certain time, cerebral cortex and hippocampus of rats appear senescence characteristics such as irregular nucleus, nuclear apoptosis and so on, which shows subacute aging model can become brain senescence model.Treadmill exercises in 6 weeks has a better effect on improving the learning ability of rats than small load exercises.Treadmill exercises in 6 weeks can stimulate the activity of SOD、GSH-Px and reducethe amount of MDA、LPO in rats cerebral cortex and hippocampus effectively,delaying the procession of senescence of central nervous system and strengthening the learning memory ability, which shows proper exercises can improve antioxidant capacity of organism andrestrain lipid peroxidation.Key words: senescence exercise D-galactose cerebral cortex hippocampus free radicalVI缩略词英文缩写英文全称中