NLRP3炎性体与类风湿关节炎相关性研究.docVIP

NLRP3炎性体与类风湿关节炎相关性研究 　　[摘要] 目的 探讨NLRP3炎性体与类风湿关节炎的相关性。 方法 选取2015年1～12月我院收治的类风湿关节炎患者（RA）40例为研究组，同时选取同期健康体检人员40例为对照组，比较两组研究对象外周血NLRP3、半胱天冬酶-1（CASP1）以及凋亡斑点样蛋白（PYCARD）mRNA表达水平。 结果 研究组的NLRP3表达显著低于对照组，同时CASP1以及PYCARD表达显著高于对照组，差异均有统计学意义（P0.05）。 结论 NLRP3炎性体各个基因mRNA表达在类风湿关节炎患者当中表达异常，表明NLRP3炎性体在炎症反应中有重要影响。 　　[关键词] NLRP3炎性体；类风湿关节炎；自身免疫性疾病；相关性 　　[中图分类号] R593.22 [文献标识码] A [文章编号] 1673-9701（2017）11-0008-03 　　Study on the correlation between NLRP3 inflammasome and rheumatoid arthritis 　　SONG Xiandong1 LI Yang2 LIU Bo1 YAN Zhaowei1 ZHU Min3 　　1.Department of Second Orthopedics， Hongqi Hospital Affiliated to Mudanjiang Medical College， Mudanjiang 157011， China； 2.Department of First Orthopedics， Hongqi Hospital Affiliated to Mudanjiang Medical College， Mudanjiang 157011， China； 3.Department of Radiology， Hongqi Hospital Affiliated to Mudanjiang Medical College， Mudanjiang 157011， China 　　[Abstract] Objective To investigate the relationship between NLRP3 inflammasome and rheumatoid arthritis. Methods Forty patients with rheumatoid arthritis（RA） admitted in our hospital from January to December 2015 were chosen as study group. 40 healthy subjects in the same period were selected as the control group. The mRNA expression levels of NLRP3， caspase-1（CASP1） and apoptotic spot-like protein（PYCARD） in peripheral blood between the two groups were compared. Results The expression of NLRP3 in the study group was significantly lower than that in the control group， and the expressions of CASP1 and PYCARD were significantly higher than those of the control group（P0.05）. Conclusion The mRNA expression of each NLRP3 inflammasome gene in rheumatoid arthritis is abnormal， indicating that NLRP3 inflammasome has important effect in inflammatory response. 　　[Key words] NLRP3 inflammasome； Rheumatoid arthritis； Autoimmune diseases； Relevance 　　?风湿关节炎（rheumatoid arthritis，RA）属于自身免疫性疾病的一种，临床表现主要是关节滑膜炎症，关节出现对称性破坏，能够导致患者关节软骨以及关节囊破坏，严重情况下会使患者的关节功能丧失甚至残毁畸形[1]。该病的发病机制还不够明确，研究发现疾病发生发展的过程涉及到免疫反应及各种细胞因子的参与