MTA3和E―cadherin在宫颈癌转移中作用研究.docVIP

MTA3和E―cadherin在宫颈癌转移中作用研究 　　【摘要】 目的：研究MTA3及E-cadherin蛋白在宫颈癌中的表达，并分析两者间的相互关系。方法：利用免疫组化染色SABC法检测68例人体宫颈癌标本中MTA3和E-cadherin蛋白的表达。结果：MTA3蛋白的表达与宫颈癌的组织学分级有密切关系（ 字2=4.484，P=0.034），与患者的年龄、肿瘤的组织学分级、临床分期、是否有淋巴结或远处转移无关（P0.05）。肿瘤组E-cadherin存在表达减少或丢失的比率明显高于正常对照组（ 字2=21.761，P=0.00003），并与淋巴结转移有密切关系（ 字2=14.686，P=0.0001），而与患者的年龄、肿瘤的组织学分级、临床分期及远处转移等无关（P0.05）。在宫颈癌组织中，MTA3与E-cadherin的表达呈正相关（r=0.579，P=0.0002）。结论：E-cadherin蛋白表达减少或缺失与宫颈癌浸润转移具有良好的相关性，MTA3表达下调的宫颈癌细胞可能更具侵袭潜能，MTA3可能是宫颈癌EMT启动调控的因素之一。 　　【关键词】 子宫颈癌； 转移相关因子3； 上皮间质化； 转移 　　Study the Relationship between the Expression of MTA3 and E-caderin on the Metastasis of Cervical Cancer/HUANG Hai-hua，WU Xiu-qian，LI Zhen-hua，et al.//Medical Innovation of China，2016，13（28）：014-018 　　【Abstract】 Objective：To explore the expression of MTA3 and E-cadherin，to analyse potential correlation between these two proteins in cervical cancer.Method：68 patients with cervical cancer of MTA3 and E-cadherin expression were analyzed by immunohistochemically.Result：The expression of MTA3 was closely related to cervical cancer histological grading（ 字2=4.484，P=0.034），it was not related to the age，tumor histological grade，clinical stage，lymph node metastasis or distant metastasis（P0.05）.In tumor group， the rate of loss or low expression of E-cadherin was significantly higher than that of normal control group （ 字2=21.761，P=0.00003），which had close relation with lymph node metastasis（ 字2=14.686，P=0.0001），it was not related to the age，tumor histological grade，clinical stage or distant metastasis（P0.05）.In cervical cancer tissues， the expression of MTA3 had a positive correlation with the expression of E-cadherin （r=0.578，P=0.0002）.Conclusion：There are good correlation between loss or low expression of E-cadherin expression and cervical cancer metastasis.Cervical cancer cells that have low expression of MTA3 may be more aggressive.MTA3 may be one of the factors of cervical cancer EMT launch control. 　　【Key words】 Cervical cancer； Metastasis-associated gene 3； Epi