TLRsMyD88与痛风性关节炎相关性研究.docVIP

TLRsMyD88与痛风性关节炎相关性研究 　　【摘 要】目的：研究Toll?邮芴?2（TLR2）、Toll样受体4（TLR4）、髓样分化因子88（MyD88）与痛风性关节炎患者临床及实验室指标的相关性。方法：选取120例痛风性关节炎患者，其中急性痛风性关节炎患者（急性组）76例，非急性痛风性关节炎患者（非急性组）44例；另选取健康者20例为健康对照组。记录所有患者的一般情况、病程、疼痛视觉模拟评分法（VAS）评分，检查肾功能、C-反应蛋白（CRP）、红细胞沉降率（ESR），酶联免疫吸附测定法（ELISA）检测TLR2、TLR4、MyD88在外周血的浓度，采用SPSS 22.0软件分析痛风性关节炎患者的外周血TLR2、TLR4、MyD88与各指标的相关性。结果：①痛风性关节炎患者外周血TLR2、TLR4、MyD88浓度较健康对照组显著升高，差异有统计学意 　　义（P 10年的患者外周血TLR2、TLR4、MyD88比较，病程 0.05）。急性组患者VAS评分、ESR、CRP高于非急性组，差异有统计学意义（P 0.05）。④痛风性关节炎患者外周血TLR2、TLR4、MyD88与CRP、ESR呈线性正相关（P 0.01或P 0.05）。结论：TLR2、TLR4、MyD88参与了痛风性关节炎患者的发生、发展，尤其在急性期。 　　【关键词】 痛风性关节炎；Toll样受体；髓样分化因子88；相关性 　　【ABSTRACT】Objective：To study the correlation between clinical and laboratory indexes of TLR2， TLR4 and MyD88 in patients with gouty arthritis.Methods：One hundred and twenty cases of gouty arthritis were divided into an acute group（76 cases）and a non-acute group（44 cases），and twenty 20 healthy people were chosen as a control group.The general condition，course of disease，pain visual analogue scale（VAS）scores of all patients were recorded.The renal function，C-reactive protein（CRP）and erythrocyte sedimentation rate（ESR）were checked.The enzyme linked immunosorbent assay（ELISA）were used to detect the concent- 　　rations of TLR2，TLR4，MyD88 in peripheral blood，and the software SPSS 22.0 was used to analyze the correlation between TLR2，TLR4 and MyD88 in peripheral blood and all the indexes.Results：①The concentrations of TLR2， 　　TLR4 and MyD88 in the peripheral blood of patients with gouty arthritis were significantly higher than those in the healthy control group，and the difference was statistically significant（P 0.01）.The concentrations of TLR2，TLR4 and MyD88 in the peripheral blood of the acute group was significantly higher than those in the non-acute group（P 0.01）.②Comparison among patients respectively with disease course of less than 　　1 year，1～5 years，5～10 years and over 10 years，TLR2 and TLR4 of those with less than 1 year of disease course were higher，and th