乌司他丁对蜂蛰伤患者心肌损伤保护作用.docVIP

乌司他丁对蜂蛰伤患者心肌损伤的保护作用 　　【摘要】 目的 探讨乌司他丁对蜂毒致心肌损伤的保护作用。方法 58例蜂毒致心肌损伤患者随机分为两组， 均给予西医常规治疗， 在此基础上， 治疗组28例予以乌司他丁静脉滴注， 对照组30例予以果糖二磷酸钠静脉滴注。检测两组心肌酶谱[肌酸激酶（CK）、肌酸激酶同工酶（CK-MB）、乳酸脱氢酶（LDH）]在入院当天、48 h及7 d后的水平， 而超敏C反应蛋白（hs-CRP）以及血浆丙二醛（MDA）、超氧化物歧化酶 （SOD）、白介素6（IL-6）分别在入院当天及7 d后检测变化情况。结果 入院时两组患者血浆CK、CK-MB、LDH等心肌酶指标比较差异无统计学意义（P0.05）；治疗48 h后， 治疗组心肌酶各项指标较对照组低， 差异有统计学意义（P0.05）， 治疗7 d后两组患者心肌酶各项指标比较， 治疗组优于对照组， 差异有统计学意义（P0.05）；治疗7 d后对照组血浆MDA、hs-CRP、IL-6较治疗组高， 而SOD较低， 差异均有统计学意义（P0.05）。结论 乌司他丁对蜂毒致心肌损伤有较好的保护作用， 其机制可能与抗氧化应激、抗炎有关。 　　【关键词】 蜂蛰伤；心肌损伤；乌司他丁；氧化应激 　　DOI：10.14163/j.cnki.11-5547/r.2015.29.002 　　Protective effect by ulinastatin for myocardial damage in bee sting injury patients RAN Jing-bing， WEI Pu-cheng， LIU She-yang， et al. Department of Intensive Medicine， Hechi City People’s Hospital， Hechi 547000， China 　　【Abstract】 Objective To investigate protective effect by ulinastatin for bee venom-induced myocardial damage. Methods A total of 58 patients with bee venom-induced myocardial damage were randomly divided into two groups. Both group received conventional treatment by Western medicine. The treatment group with 28 cases received intravenous drip of ulinastatin， and the control group with 30 cases received intravenous drip of fructose dipllosphate sodium. Myocardium enzymogram levels [creatine kinase （CK）， creatine kinase-MB （CK-MB）， lactic dehydrogenase （LDH）] were detected in the two groups at admission and after 48 h and 7 d. Changes of high sensitivity C-reactive protein （hs-CRP）， serum malonaldehyde （MDA）， superoxide dismutase （SOD）， and interleukin-6 （IL-6） were detected at admission and after 7 d. Results At their admission， the two groups had no statistical significance in differences of plasma CK， CK-MB， LDH indexes （P0.05）. After 48 h of treatment， the treatment group had lower indexes than the control group， and their difference had statistical significance （P0.05）. After 7 d of treatment， the treatment group had better indexes than the control group， and their difference