复方丹参注射液联合硫酸镁治疗对子痫前期患者血压与尿蛋白含量影响.docVIP

复方丹参注射液联合硫酸镁治疗对子痫前期患者血压与尿蛋白含量影响 　　【摘要】 目的：探讨复方丹参注射液联合硫酸镁治疗子痫前期的临床疗效。方法：选取笔者所在医院收治的子痫前期孕妇216例作为研究对象，对照组108患者给予硫酸镁降压治疗，试验组108例患者在此基础上加用复方丹参注射液联合治疗。对比两组患者血压、尿蛋白含量变化及治疗效果。结果：试验组总有效率（95.4%）明显高于对照组，差异有统计学意义（字2=17.755，P0.05）；治疗后试验组平均动脉压（90.5±24.2）mm Hg，24 h尿蛋白含量（323.1±31.4）mg，明显低于对照组，差异有统计学意义（P0.05）。结论：复方丹参注射液联合硫酸镁治疗子痫前期，降血压、降低尿蛋白效果理想，不良反应较少，值得临床推广应用。 　　【关键词】 复方丹参注射液； 硫酸镁； 子痫前期 　　中图分类号 R256 文献标识码 A 文章编号 1674-6805（2014）11-0012-02 　　Effect of Danshen Injection Combined Magnesium Sulfate on Blood Pressure and Urine Protein Levels in Patients with Preeclampsia/WEN Jian-zhong.//Chinese and Foreign Medical Research，2014，12（11）：12-13 　　【Abstract】 Objective：To investigate the clinical efficacy of Danshen injection combined with magnesium sulfate therapy in patients with preeclampsia.Method：216 pregnant women with preeclampsia in our hospital were as the research object，108 patients in the control group were given magnesium sulfate antihypertensive treatment，the other 108 patients in the treatment group were given Danshen injection based on the use of magnesium sulfate.Blood pressure，urine protein in two groups of patients and the treatment effect were compared.Result：The total efficiency of the treatment group was 95.4%，significantly higher than that in the control group（字2=17.755，P0.05）.After treatment，mean arterial pressure was （90.5±24.2）mm Hg in the treatment group，24 h urine protein levels was（323.1±31.4）mg，significantly lower than that in the control group（P0.05）.Conclusion：Danshen injection combined with magnesium sulfate for treatment of preeclampsia，can lower blood pressure，reduce urinary protein，has fewer side effects，is worthy of clinical application. 　　【Key words】 Danshen injection； Magnesium sulfate； Preeclampsia 　　First-author’s address：Meizhou Maternal and Child Health Hospital，Meizhou 514021，China 　　子痫前期是产科常见病，随着经济的发展，人们生活水平的提高，饮食结构的改变，加上久坐、缺乏运动等不良生活方式的影响，子痫前期的发病率一直居高不下[1]。临床孕妇表现为下肢水肿、头晕、测量血压≥140/90 mm Hg、尿蛋白含量增加。传统上多采用硫酸镁注射液治疗子痫前期[2]。但有报道称，小剂量硫酸镁降压效果不明显，大