奥拉西坦对脑梗死急性期认知功能障碍改善作用及安全性分析.docVIP

奥拉西坦对脑梗死急性期认知功能障碍改善作用及安全性分析 　　[摘要] 目的 观察奥拉西坦对脑梗死急性期认知功能障碍的改善作用及安全性。 方法 选取在我院治疗的脑梗死急性期合并认知功能障碍患者60例作为观察对象，随机分为两组，每组30例，对照组在常规治疗的基础上加用吡拉西坦，观察组在常规治疗的基础上联合奥拉西坦进行治疗。比较两组患者治疗前后的认知功能障碍（MMSE）、事件相关电位P300（波潜伏期、波幅）的改善情况及不良反应。 结果 治疗后，观察组患者的MMSE评分、P300波潜伏期、波幅均优于对照组（P0.05）；且观察组不良反应发生率为3.33%，明显低于对照组的20.00%（P0.05）。 结论 奥拉西坦治疗脑梗死急性期合并认知功能障碍的效果可观，安全性高，值得广泛推广。 　　[关键词] 脑梗死急性期；认知功能障碍；安全性；奥拉西坦 　　[中图分类号] R743 [文献标识码] B [文章编号] 1673-9701（2017）03-0092-03 　　Effect and safety of oxiracetam on cognitive dysfunction in patients with acute cerebral infarction 　　QU Na1 NA Lisha1 LI Zhaosheng2 CAO Wenhui2 　　1.Department of Pharmacy， Hongqi Hospital Affiliated to Mudanjiang Medical College， Mudanjiang 157011， China； 2.Department of the Second Neurology， Hongqi Hospital Affiliated to Mudanjiang Medical College， Mudanjiang 157011， China 　　[Abstract] Objective To observe the effect and safety of oxiracetam on acute cognitive impairment in patients with acute cerebral infarction. Methods Sixty patients with acute cerebral infarction combined with cognitive dysfunction treated in our hospital were selected as subjects. The patients were randomly divided into two groups with 30 cases in each group. In the control group， piracetam was added to the patients with acute cerebral infarction and cognitive dysfunction besides conventional treatment. The patients in the observation group were treated with oxiracetam on the basis of routine therapy. Mini-Mental State Exam（MMSE）， event-related potential P300（wave latency and amplitude） before and after treatment， and the probability of occurrence of adverse events were compared. Results After treatment， the MMSE score， P300 wave latency and amplitude of observation group were better than those of the control group（P0.05）. The adverse reaction rate of the observation group was 3.33%， significantly lower than the control group（20.00%）（P0.05）. Conclusion Oxiracetam in treatment of acute cerebral infarction combined with cognitive dysfunction is safe and effecti