感染性腹泻病和溃疡性结肠炎患儿血清IL17水平变化及意义.docVIP

感染性腹泻病和溃疡性结肠炎患儿血清IL17水平变化及意义 　　[摘要] 目的 探讨IL-17在感染性腹泻病和溃疡性结肠炎发病中的意义。方法 采用流式细胞仪检测35例感染性腹泻病患儿(其中急性感染性腹泻组10例,迁延性感染性腹泻组15例,慢性感染性腹泻组10例)、7例溃疡性结肠炎患儿(溃疡性结肠炎组)和8例健康体检者(对照组)血清IL-17水平。结果 (1)感染性腹泻组和溃疡性结肠炎组血清IL-17水平均明显高于对照组(P0.05),溃疡性结肠炎组高于感染性腹泻组(P0.05);(2)迁延性感染性腹泻组和慢性感染性腹泻组血清IL-17水平均明显高于对照组(P0.01),慢性感染性腹泻组高于急性感染性腹泻组(P0.01)。结论 IL-17参与了感染性腹泻病及溃疡性结肠炎的发病机制,且与病程、炎症程度密切相关,在慢性感染性腹泻及溃疡性结肠炎中表达更高,但确切关系及具体机制仍有待进一步研究。 　　[关键词] 感染性腹泻病; 溃疡性结肠炎; IL-17 　　[中图分类号] R574.62 [文献标识码] A [文章编号] 1673-9701(2010)05-58-02 　　 　　Serum IL-17 Level in Infant Infectious Diarrhea and Ulcerative Colitis 　　NIU Wenyuan ZHANG Meixi ZHAO Qing YUAN Huiyun YANG Tanbao QIN Hairong 　　Digestive System Department,Shanxi Childrens Hospital,Taiyuan 030001,China 　　 　　[Abstract] ObjectiveTo investigate the significance of serum IL-17 in infectious diarrhea and lcerative colitis. MethodsSerum IL-17 was detected by Flow Cytometry,including 35 cases of infectious diarrhea(10 cases of acute infectious diarrhea,15 of persistent infectious diarrhea and 10 of chronic infectious diarrhea),7 cases of ulcerative colitis(ulcerative colitis group)and 8 cases of healthy controls(negative control). Results1.The serum IL-17 level of the infectious diarrhea and ulcerative colitis group was significantly higher than that of the control group(P0.05),and that of the ulcerative colitis group was higher than that of the infectious diarrhea group(P0.05). 2.The serum IL-17 level in persistent infectious diarrhea and chronic infectious diarrhea was much higher than that of the control group(P0.01),and that in chronic infectious diarrhea was higher than that in acute infectious diarrhea(P0.01). ConclusionIL-17 participates in the pathogenesis of infectious diarrheal diseases and ulcerative colitis,and is closely related to the course of disease and the degree of inflammation,showing much higher serum IL-17 level in chronic infectious diarrhea and ulcerative colitis. 　　[Key words]Infectious diarrhea; Ulcerative colitis; IL-17 　　 　　感染性腹泻病与溃