戊酸雌二醇联合醋酸甲羟孕酮治疗流产不全临床疗效分析.docVIP

戊酸雌二醇联合醋酸甲羟孕酮治疗流产不全临床疗效分析 　　[摘要] 目的 分析戊酸雌二醇与醋酸甲氢孕酮联合治疗流产不全的临床疗效与用药后不良反应。方法 整群该院2013年2月―2015年2月诊治流产孕妇共152例，其中81例孕妇存在流产不全，将流产不全的孕妇作为该次研究对象，按用药方式不同将其分为常规组（n=40）与联合组（n=41），常规组给予临床催产素药物治疗，联合组采用戊酸雌二醇+醋酸甲氢孕酮联合治疗，观察两组患者出血情况、治疗效果与用药不良反应。结果 联合组患者出血时间、出血量分别为（7.28±2.79）min、（11.03±5.27）mL均高于联合组（P0.05），治愈率97.56%优于常规组55%，不良反应发生率4.88%明显低于常规组，差异有统计学意义（P0.05）。结论 采用戊酸雌二醇+醋酸甲氢孕酮联合治疗对流产不全具有显著疗效，可明显缩短阴道持续出血时间，安全可靠，不良反应较轻，值得临床广泛使用。 　　[关键词] 戊酸雌二醇；醋酸甲氢孕酮；催产素；流产不全；疗效；不良反应 　　[中图分类号] R246.3 [文献标识码] A [文章编号] 1674-0742（2016）10（b）-0154-03 　　[Abstract] Objective To study the clinical effect and adverse reactions of estradiol valerate and medroxyprogesterone in the treatment of incomplete abortion. Methods Group selection 152 cases of adopting the induced abortion from February 2013 to February 2015 in our hospital were selected. There were 81 cases of incomplete abortion. The subjects were divided into conventional group （40 cases） and combined group （41 cases） according to the different medication methods. The conventional group took oxytocin； the combined group took estradiol valerate and medroxyprogesterone. The bleeding condition， clinical effect and adverse reactions for two groups were observed. Results Patients in the combined group bleeding time and bleeding volume were （7.28 ±2.79） min， （11.03 ± 527） mL were higher than combined group （P 0.05） cure rate was 97.56% better than the conventional group 55%， incidence of adverse reactions to 4.88% was significantly lower than the conventional group， the difference was statistically significant （P 0.05）. Conclusion The estradiol valerate and medroxyprogesterone has an obvious effect in patients with incomplete abortion， shortens the duration of vaginal bleeding， improves the clinical safety and reduces the adverse event rate. It is worthy of clinical application. 　　[Key words] Estradiol valerate； Medroxyprogesterone； Oxytocin； Incomplete abortion； Clinical effect； Adverse reaction 　　流产不全作为临床常见的人工流产并发症之一[1]，常发生在妊娠8～12周，宫内胎儿虽已排出，但部分或全部胎盘