早产儿血清25羟基维生素D3水平与超声骨密度相关性研究.docVIP

早产儿血清25羟基维生素D3水平与超声骨密度相关性研究 　　[摘要]目的 探?早产儿血清25羟基维生素D3水平与超声骨密度的相关性。方法 选取2014年5月～2017年2月在南方医科大学附属小榄医院出生、住院的新生儿76例，其中足月儿组30例，早产儿组46例，记录出生时的基本情况，利用定量超声技术测定早产儿组和足月儿组出生后24 h内胫骨中段骨密度值（SOS），测定早产儿组和足月儿组出生24 h内血清25羟基维生素D3、甲状旁腺素（PTH）、钙（Ca）、磷（P）及碱性磷酸酶（ALP）水平。早产儿组以出生时血浆25羟基维生素D3水平第50百分位数（38 ng/ml）为截点，分为早产儿A组（≥38 ng/m，共26例）和早产儿B组（0.05）。④早产儿A组和早产儿B组两组之间胫骨骨密度、PTH、钙离子、25羟基维生素D3水平比较均有显著性差异（P0.05）。⑤早产儿组出生时25羟基维生素D水平与Ca、胫骨骨密度、PTH呈正相关（P0.05）。结论 ①早产儿出生时胫骨骨密度、血清25羟基维生素D3水平明显低于足月儿；②出生时血清25羟基维生素D3水平高的早产儿胫骨超声骨密度优于血清25羟基维生素D3水平低的早产儿，故补充25羟基维生素D3对促进早产儿骨生长、预防早产儿代谢性骨病有重要意义。 　　[关键词]早产儿；定量超声；骨密度；血清25羟基维生素D3 　　[中图分类号] R715.8 [文献标识码] A [文章编号] 1674-4721（2017）05（a）-0106-04 　　[Abstract]Objective To investigate the correlation between serum 25-hydroxy vitamin D3 levels and bone mineral density in premature infants.Methods 76 neonates were born and hospitalized in Xiaolan Hospital Affiliated to Southern Medical University from May 2014 to February 2017.Among them，there were 30 cases of term infants and 46 cases of preterm infants.The basic situation was recorded at birth，The bone mineral density （SOS） of the middle tibia was measured within 24 hours after birth in the preterm infantile and term infants by quantitative ultrasound.The serum 25-hydroxy vitamin D3，parathyroid hormone （PTH），calcium （Ca），phosphorus （P） and alkaline phosphatase （ALP） levels in the preterm infants were measured at the 50th percentile （38 ng/ml） （≥38 ng/ml，26 cases） and preterm children B group （0.05）.There were significant differences in tibial bone mineral density，PTH，calcium ion and 25-hydroxy vitamin D3 between group A and group B （P0.05）.⑤There was a positive correlation between the level of 25-hydroxy vitamin D3 and Ca，tibial bone mineral density and PTH （P0.05）.Conclusion ①The density of tibial bone and the content of 25-hydroxy vitamin D3 in premature infants were significantly lower than those of term infants.②The bone mineral density of tibial ultrasound in preterm infants with high levels of 25-hydroxy vitamin D3