温阳利水法治疗慢性心衰疗效观察.docVIP

温阳利水法治疗慢性心衰疗效观察 　　摘要：目的探讨温阳利水法对慢性心衰的疗效。方法选用本院门诊及住院心衰患者且中医诊断为心衰心肾阳虚证型者80例，采取随机单盲法分为治疗组40例，对照组40例，对照组给予西药治疗，治疗组在对照组治疗的基础上，加用温阳利水免煎剂。观察以下指标：①中医证候积分、NYHA分级。②心功能各参数：LVEF%、6 min步行试验（6MWT）、血清 BNP、可溶性ST2、[KG（0.1mm]半乳糖凝集素3。③血清生化指标超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GPX）、血红素氧合酶（HO-1）水平。分析各组的上述各项指标的变化。结果2组患者治疗组中医证候、NYHA分级明显改善，对比差异有统计学意义（P005）；2组治疗后各心功能指标（LVEF、6min步行距离、BNP、可溶性ST2、半乳糖凝集素3）较治疗前有明显改善（P005），且治疗组优于对照组（P005）；2组治疗后SOD、GPX、HO-1表?_较治疗前明显升高（P005），且治疗组的表达高于对照组（P005）。结论温阳利水法能改善CHF患者心功能及减轻临床症状，其机制与抗氧化应激有关。[KG）] 　　关键词：温阳利水法；心衰病；可溶性ST2；半乳糖凝集素3 　　中图分类号：R5416文献标志码：B文章编号：1007-2349（2017）08-0028-03 　　[WT5HZ][JZ]Observation on Curative Effect of Wenyang Lishui Method in the Treatment of Chronic Heart Failure 　　[WT5BZ][JZ]CAI Juan，ZHENG Xiao-dan，NI Wei-bing 　　[WT5BX][JZ]（Nantong Chinese Medicine Hospital of Jiangsu Province，Nantong，Jiangsu 226001） 　　[WTHZ]【Abstract】[WTBZ]Objective：To explore the effect of Wenyang Lishui on chronic heart failureMethods：80 outpatient and hospitalized heart failure patients with heart-kidney yang deficiency in our hospital were divided into a treatment group and a control group by randomized single blind method，40 cases per groupThe control group was treated with western medicine while the treatment group was added Wenyang Liyu decoction besides the western medicine of the control groupThe observed indicators were as follows，ATCM syndrome score，NYHA classificationBCardiac function parameters：LVEF%，6 min walking test（6MWT），serum BNP，soluble ST2，galactoside 3CSerum biochemical index changes of superoxide dismutase（SOD），glutathione peroxidase（GPX）and heme oxygenase（HO-1）The above indicator changes of each group were measured analyzedResults：The TCM syndrome and NYHA grade of the two groups were significantly improved and the contrast difference was statistical significance（P005）The cardiac function indexes（LVEF，6min walking distance，BNP，soluble ST2，galactose 3）of the two groups were significantly batter than prior treatment（P005）The treatment group was better