精浆抗苗勒氏管激素与不育症精液参数相关性研究.docVIP

精浆抗苗勒氏管激素与不育症精液参数相关性研究 　　【摘要】目的：探讨精浆中抗苗勒氏管激素（AMH）水平与男性不育症精液参数的相关性。方法：选取门诊就诊的男性不育症患者56例为不育组，另设有生育史的健康男性41例作为正常对照组，两组均检测精浆中抗苗勒氏管激素（AMH）、精液参数（精子的密度、活率、活力及畸形率），不育组测定血清性激素6项。结果：1不育组与正常对照组年龄、禁欲时间无明显差异；2不育组及正常对照组精浆AMH与a级精子率、精子活力、精子存活率呈正相关（P001），与形态相关性，不育组与正常对照组精浆AMH值无明显差异；3不育组精液分析正常患者精浆AMH显著高于弱精子症患者（P≤001），形态正常患者与形态异常患者精浆AMH无明显差异，不育组精浆AMH与性激素无明显相关性。结论：精浆AMH与a级精子百分率、精子活力、精子活率呈正相关。精浆AMH会随着不育症精液分析结果改善而提高，而与不育状态无关，可作为临床检验不育症治疗效果指标。 　　【关键词】抗苗勒氏激素；不育症；精液参数 　　The correlation ofseminal anti-mullerian hormone and infertility semen parametersZHANG Zhijie1， CHEN Xiaojun1， ZHAO Meng2， ZHANG Yueyang3， DUAN Pingchuan1， JIA Yusen1△. 1. Andrology Urology Department， Beijing University of Chinese Medicine Affiliated Oriental Hospital， Beijing 100078， China； 2. Operation room， Beijing University of Chinese Medicine Affiliated Oriental Hospital， Beijing 100078， China； 3. Andrology Department， Wangjing Hospital of China Academy of Chinese Medical Sciences， Beijing 100102， China 　　【Abstract】Objectives： To explore the correlation of seminal anti-mullerian hormone （AMH） levels and male infertility semen parameters. Methods： 56 patients in the male infertility clinic were selected as infertility and another 41 healthy male with reproductive history were selected as the control group. The seminal plasma AMH and semen parameters （sperm concentration， motility， viability and malformation rate） in both groups were detected. The serum sex hormone of infertility group was detected. Results： 1. Infertility group and control group had no significant difference in age and abstinence time. 2. AMH was positively correlated （P001） with class A sperm rate， sperm motility and sperm viability， and correlation with morphological. The infertility group and the control group had no significant difference in seminal AMH value. 3. Seminal AMH of infertile patients with normal semen analysis was significantly higher than in patients with weak sperm （P≤001）， and had no significant difference in normal and abnorm