黄芩油膏对肺癌分子靶向治疗相关性皮肤毒性反应预防作用.docVIP

黄芩油膏对肺癌分子靶向治疗相关性皮肤毒性反应预防作用 　　【摘要】 目的：研究黄芩油膏对肺癌患者分子靶向药物引起的皮肤毒性反应的预防作用。方法：服用分子靶向药物的肺癌患者随机分为试验组30例和对照组30例，试验组在常规治疗基础上使用黄芩油膏外涂于皮肤毒性反应好发部位。观察瘙痒、斑丘疹、疱疹、局部脱屑、皮肤损害面积、指甲/甲周改变等皮肤毒性反应。记录首发皮肤损害时间及皮肤损害病程。结果：试验组皮肤毒性反应人数明显少于对照组，差异有统计学意义（P0.05）。两组不同级别指甲/甲周严重程度比较差异无统计学意义（P0.05）。试验组患者的皮损病程（18.11±4.41）周，明显短于对照组的（21.46±3.91）周，差异有统计学意义（P0.05）。试验组患者的首发皮损时间（29.79±8.32）d，明显晚于对照组的（22.96±6.91）d，差异有统计学意义（P0.05）。结论：黄芩油膏对于肺癌患者分子靶向药物引起的皮肤毒性反应的有一定预防作用，能延迟皮肤毒性反应出现和缩短病程。 　　【关键词】 肺癌； 黄芩油膏； 分子靶向治疗； 皮肤毒性反应 　　doi：10.14033/j.cnki.cfmr.2018.2.002 文献标识码 A 文章编号 1674-6805（2018）02-0003-03 　　【Abstract】 Objective：To detect preventive effect of Huangqi Ointmentn on molecular targeted treatment induced skin toxicity in lung cancer patients.Method：Lung cancer patients were randomly divided into the experimental group（30 cases） and the control group（30 cases）.On basis of the ordinary treatment，Huangqin Ointment was given on skin toxicity prone area of patients in the experimental group.Skin toxicity including pruritus，maculopapule，herpes，local desquamation，skin lesion area，nail/peri-nail change，etc were observed.The appearance of the initial skin lesion and the course of skin lesions were recorded.Result：The skin toxicity of the experimental group was milder than the control group（P0.05）.The course of skin lesions in the experimental group was （18.11±4.41）weeks，significantly shorter than （21.46±3.91）weeks in the control group（P0.05）.The appearance of the initial skin lesion was （29.79±8.32）days in the experimental group，which was significantly later than （22.96±6.91）days in the control group（P0.05）.Conclusion：Huangqin Ointment has preventive effect on skin toxicity associated with molecular targeted treatment in lung cancar patients.It can delay occurs and shorten the course of skin toxicity. 　　【Key words】 Lung cancer； Huangqin Ointment； Molecular targeted treatment； Skin toxicity 　　First-author’s address：Affiliated Hospital of Nanjing University of Chinese Medicine，Nanjing 210029，China 　　肺癌是目前发病率和病死率最高的恶性