芬戈莫德(FTY720)对实验性自身免疫性脑脊髓炎小鼠细胞因子表达的影响-神经病学专业论文.docxVIP

万方数据 万方数据 目 录 中文摘要··········································································································1 英文摘要···································································································4 英文缩写·······································································································7 研究论文 芬戈莫德（FTY720）对实验性自身免疫性脑脊髓炎小鼠细胞 因子表达的影响 前言·································································································8 材料与方法······························································································10 结果··········································································································17 附图·································································································20 附表·········································································································23 讨论································································································24 结论··································································································29 参考文献·························································································30 综述 芬戈莫德对 EAE 治疗的作用机制及 EAE 相关细胞因子免疫学 机制 33 致谢···········································································································46 个人简历······························································································47 中 文 摘 要 芬戈莫德（FTY720）对实验性自身免疫性脑脊髓炎小鼠细胞因 子表达的影响 摘 要 目 的 ： 多 发 性 硬 化 （ multiple sclerosis, MS ） 是 以 中 枢 神 经 系 统 （CNS）白质的脱髓鞘病变作为特点，遗传易感个体与环境因素共同作 用发生的自身免疫性疾病。其病因和机制尚未完全明确，但目前发现一 些炎性细胞因子是导致其发生的主要原因。各种细胞因子以自分泌或者 旁分泌的形式，参与该疾病免疫反应和组织修复过程，并且对多发性硬 化病情的严重程度和发展起决定性作用。实验性自身免疫性脑脊髓炎 （EAE）是一种以特异性致敏的 CD4+T 细胞介导为主，以中枢神经系统 HYPERLINK /doc/5331357-5566594.html 内小血管周围出现的单个核细胞浸润及髓鞘脱失为特征的自身免疫性疾 病，是人类多发性硬化（MS）病研究的理想动物模型，对研究临床神经 免疫学具有重要意义。芬戈莫德（fingolimod, FTY720）是从冬虫夏草中 提取的有效成分-多球壳菌素（myriocin, ISP-1）通过去除手性中心、改 变侧链等处理而合成的新型免疫抑制剂。FTY720 的免疫抑制主要通过 激动