健脾利胆片治疗胆囊炎的临床与实验研究-中西医结合内科专业论文.docxVIP

y≤04 y≤04 398 提 要 本研究旨在从理论、临床与实验诸方面对健脾利胆片治疗脾虚 型胆囊炎的机理进行系统探讨，以寻求一种新的治疗思路、方法和 有效药物。研究认为，肝郁脾虚是本病的主要病机，健脾利胆为其 主要治则。临床以健脾利胆片治疗54例作为治疗组，以利胆片治 疗36例作为对照组，将患者的症状、体征及B超检查作治疗前后对 比。结果表明，该方不仅能明显改善患者全身症状，而且能显著提 高胆囊收缩率，恢复B超下胆囊正常形态。治疗组的总有效率达 90．74％，而对照组的总有效率为58．33％，两组比较有显著差异(P 0．01)。实验研究表明，该药可显著增加脾虚大鼠的胆j十分泌量， 改善脾虚家兔的胆囊收缩功能，并具有抗菌、消炎的作用。(证实了 健脾利胆片具有健脾利胆的确切作用，且服用方便，无毒副作用，是 目前临床上治疗脾虚型胆囊炎的有效制剂。y 主题词 胆囊炎健脾利胆片 临床研究实验研究 注：本课题是山东省中医管理局专项资助课题的部分内容 Clinical Clinical and Experimental Study Oil Jian Pi Li Dan Tablet in Treating cholecystits Sepeciality：Internal Medicine of Integrated Traditional and研esI枷 Medicine．Research of Digestive System Disease Author：Wang Weimi馏 Tutor：鼬厂．Zhu Dejun Abstract The aim of this study was to nlake a systematic inquire into the mechanism of Ji∞ Pi“DanTabletintreating cholecystitis ofw划m∞s ofthe spleenin dl∞mdcaI·Clini_ cal and experimental aspects，and to find a Pew therapeutic thoughtI method and effec- five dmg．Research suggested that stagnation of the liver—qi and weakness of the spleen is the main pathogenesis of the disease．Jian Pi Li Dan is its main therapeutic pdnciple．In clinical study-54 cases wele treated by Jian Pi Li Dan Tablet as t_mmtn把nt group-36 c目m were treated by Li Dan Tablet∞control group，The syptoms,signsland ultrasonography of all p拍en协before and after tIeatment were obse蒯．Results showed that this tablet not only can improve patient’S general sympto瞄obviously，but also raise gallbladder contraction rate re咖蛐and pt，30ver the cholecystic normal shape under B—ultrasound．thetotal effective rate oftherapeutic groupWaS 90．‘74％。whilein COIl- tml groups。the total effective rate was 58．33％。difference of conlparison between the two groups was remarkable《PO．01)o Experimental咖dy showed that the tablet in— cRased the choleresis volume of spleen—asthenia white rat and the gallbladder conlTact function of spleen—asthenia rabbit“m艇lr㈨y．All of these proved the Jian Pi Li Dan Tablet had the pronounced effect of strengthening the spleen and cholagogie in treat