血清UCHL1水平在脑梗死超急性期病情及预后判断中的作用.docxVIP

血清UCH-L1水平在脑梗死超急性期病情及预后判断中的作 用 (贵州省铜仁市人民医院 贵州 铜仁560003)； (贵阳市乌当区人民医院贵州贵阳550006) 【摘 要】FI的：探讨血清UCH-L1水平在脑梗死超急性期病情及预后判断 屮的作用。方法：选择2013年3月到2014年3月在本院进行治疗的超急性期脑 梗死患者50例作为观察组，并选择同期在本院进行治疗的短暂性脑缺血发作患 者50例作为对照组，采用夹心ELISA对两组患者发病期内的血清UCH-UL水平进 行测定和比较。结果：观察组血清UCH-L1水平为0.22 (0.21) mu;g/L,对照组 为0.14 (0.08) mu;g/L,两组相比差异具有显著性(P0.05)；观察组患者在 入院时、入院7d的NIHSS评分分别为9 (8)分和7 (8.25)分，3个月后mRS 评分为2 (3)分，脑梗死体积为6.71 (10.51) mL,均与血清UCH-L1水平呈正 相关(P0.01)；经多因素Logistic回归分析血清UCH?L升高是高mRS评分的独 立危险因素。结论：脑梗死超急性期血清UCH-L1水平能够对病情的严重程度和 预后进行预示。 【关键词】超急性期脑梗死；血清UCH?L1水平；生物标志物 【中图分类号】R392.7 【文献标识码】B 【文章编号】1003-5028 (2015) 7-0233-02 The Effect of the Level of Serum UCH-L1 in the Hyperacute Cerebral In fa ret i on Disease Severity and Prog nosis 【Abstract] Objective:To discussion the effect of the level of serum UCH-L1 in the hyperacute cerebral in fa ret io n disease severity and prog no sis.Method:50 cases of patients with hyperacute cerebral infarction in our hospital from March 2013 to March 2013 were selected as the observation group,and 50 cases of patients with transient cerebral ischemia in our hospital were selected as the control group,Using sandwich ELISA,determining Serum UCH-L1 levels in two groups of patients in the period of onset.Result:The level of serum UCH-L1 in observation group was 0.22 (0.21)mu;g/L,control group was 0.14(0.08)mu;g/L,the differences between the two groups were all significantly； At the time of admission and 7d,the observation group NIHSS scores was 9 (8) and 7 (8.25) ,3 m on ths after the mRS score was 2 (3 points),The volume of cerebral infarction was 6.71 (10.51) mL,The correlation between the above indexes and serum UCH-L1 levels were positively (P lt; 0.01);with multivariate Logistic regression analysis,the elevation of serum UCH-L is an in depe ndent risk factor of high mRS score.C on elusion:The level of serum UCH-L1 in the hyperacute cerebral infarctio n can in dicate the disease severity and prog no sis. 【Key words] hyperacute cerebral in fa ret i on ;the level of se