生物医学工程技术Image production.pptx

Molecular Imaging Technology for DiagnosticsTypical Imaging TechniquesX-Ray Computed Tomography (X-CT);Magnetic Resonance Imaging (MRI);Positron Emission Tomography (PET);Single-Photon Emission Computed Tomography (SPECT);Optical Imaging (OI);Ultrasound image (US);……Molecular imaging in drug developmentNature Reviews Drug Development, 2008, 7, 591However, how to judge efficiently which one isthe most promising candidate for new drug?The key issues for drug development药物研发的关键问题？The activity, targeting ability and the pharmacokinetics of drug药物的活性，靶向，药物代谢等Indeed, the estimated costs of bringing a new potential drug to the end of Phase IIItrials increased approximately 2.5-fold between 1991 and 2001, from US$318 million to $802 million. Assuming a similar cost growth rate, the costs for a new approved drug in 2013 would be $1.9 billion.Molecular imaging is a key method.Abstract | Molecular imaging can allow the non-invasive assessment of biological and biochemical processes in living subjects. Such technologies therefore have the potential to enhance our understanding of disease and drug activity during preclinical and clinical drug development, which could aid decisions to select candidates that seem most likely to be successful or to halt the development of drugs that seem likely to ultimately fail. Here, with an emphasis on oncology, we review the applications of molecular imaging in drug development, highlighting successes and identifying key challenges that need to be addressed for successful integration of molecular imaging into the drug development process.Molecular imaging in drug developmentNature Reviews Drug Development, 2008, 7, 591药物研发的关键问题？药物的活性，靶向，药物代谢等Indeed, the estimated costs of bringing a new potential drug to the end of Phase III trials increased approximately 2.5-fold between 1991 and 2001, from US$318 million to $802 million. Assuming a similar cost growth rate, the costs for a new approved drug in 2013 would be $1.9 billion.X-