【医院科室学习-神经生物学】_乙酰胆碱和其他神经递质.ppt

（II）Central nicotinic receptors (including ganglion) Subunit composition of central nicotinic receptors: ?2- ?10 (the peripheral subunit as ?1) ?2- ?4 (the peripheral subunit as ?1) About ?2- ?6, ?2- ?4: Do not form homomeric receptors, no receptors with only ? or only ? subunits exist. * Common receptor types * The heteromeric ?42?23 subtype: facilitate GABAergic and glycinergic neurotransmission. Insensitive to ?-BGTX，sensitive to Kappa or F toxin. GABA glycine ?42?23 ?42?23 * The homomeric ?75 subtype: facilitate glutamatergic neurotransmission. sensitive to ?-BGTX. glutamate ?75 ?7具有?-BGTX高亲和力结合部位 ?7-10 只形成同聚体（成熟神经元细胞表面） * Gardu?o J et al. J. Neurosci. 2012;32:15148-15157 ?2012 by Society for Neuroscience 例外 Presynaptic α4β2 nicotinic acetylcholine receptors increase glutamate release and serotonin neuron excitability in the dorsal raphe nucleus. J Neurosci. 2012 Oct 24;32(43):15148-57 * Fig. 1 (A) Photomicrograph showing basalocortical PHA-L-labeled fibers in the retrosplenial granular cortex (RSG) following a series of injections of PHA-L into the medial part of the horizontal limb of the diagonal ban (HDBm). PHA-L labeled fibers are con... Localization of α7 nicotinic acetylcholine receptor immunoreactivity on GABAergic interneurons in layers I–III of the rat retrosplenial granular cortex Neuroscience, Volume 252, 2013, 443 - 459 N受体在细胞体的分布 * ?3,5,7 ?2,4 make up the channel. homomeric receptors containing ?3 in most condition. Heteromeric receptors containing ?7 (胚胎期) (III) Nicotinic receptors in autonomic ganglions 解剖分类属于外周型 亚单位组成 属于中枢 * Presynaptic nAChRs induce release of a number of neurotransmitters Postsynaptic nAChRs depolarize neurons, increase their firing rate, and can contribute to long-term potentiation * 重要的中枢作用 兴奋效应 直接--兴奋 2. 间接？ 钙依赖 效应与N受体的钙通透 激活邻近的电压依赖性钙离子通道 细胞内钙参与效应。 * 试述中枢尼古丁型乙酰胆碱受体的结构和功能特点 Question 4 Characteristics of central nicotine receptors: * Structure，subunits, * highly permeable to Ca++. consequently activat