1型糖尿病患者骨密度变化及相关因素研究.docVIP

·1490 · ·论著 · 1 型糖尿病患者骨密度变化及相关因素研究 段鹏，涂萍，吴和平，丁浔，肖魏华，万兵花，司涟，刘佳 【摘要】 目的 探讨1型糖尿病患者骨密度 (BMD) 变化及相关影响因素。方法 收集我院就诊的1型糖尿病 患者47例，对照组为40例非糖尿病健康人群。体格检查计算腰臀比 (WHR) 及体质指数 (BMI), 葡萄糖氧化酶法 检测空腹血糖 (FPG) 及餐后2 h 血 糖 ( 2 hPG)、 高效液相法检测糖化血红蛋白 (HbA,。)、 放免法检测空腹 C 肽 (FCP) 及餐后2 hC 肽 ( 2hCP) 水平，双能X 线骨密度仪测定腰椎 (L?-L4) 及左股骨颈 BMD。 结果 两组间年龄 差异无统计学意义 (P0.05),1 型糖尿病组 BMI、WHR、FCP、2 hCP、 腰椎及股骨颈 BMD 低于对照组，但 FPG、 2 hPG及 HbA,。高于对照组，差异有统计学意义 (P0.05)。 糖尿病病程、 HbA,。与腰椎及股骨颈 BMD 呈负相关 (P 0.05),FCP、2hCP 与腰椎及股骨颈 BMD 呈正相关 (P0.05)。 进行多因素回归分析发现，进入方程的为病程、 HbA,e、FCP 及 2 hCP(P0.05)。 结论 1型糖尿病患者BMD 低于健康人群，1型糖尿病患者的病程、 HbAIe、FCP、 2 hCP水平与 BMD 关系密切。 【关键词】 糖尿病，1型；骨密度；影响因素 【中图分类号】 R587.1 【文献标识码】 A doi:10.3969/j.issn.1007-9572.2013.05.012 段鹏，涂萍，吴和平，等.1型糖尿病患者骨密度变化及相关因素研究 [J]. 中国全科医学，2013,16(5): 1490- 1492.[www.chinagp. net] Bone Mineral Density in Patients with Type 1 Diabetes Mellitus and Its Associated Factors DUAN Peng, TU Ping,WU He-ping,et al. Department of Endocrine and Metabolic Diseases, the Third Hospital of Nanchang,Nanchang Key Laboratory of Diabetes,Nanchang 330009,China 【Abstract】 Objective To explore the bone mineral density(BMD)in patients with type 1 diabetes mellitus and its as- sociated factors. Methods Forty -seven patients with type 1 diabetes mellitus treated in our hospital were assigned as the study group, and 40 healthy people as the control group. Waist -to-hip ratio(WHR) and body mass index(BMI) were calculated according to physical examination results. Fasting plasma glucose(FPG)and 2 hour postprandial glucose (2 hPG) were detected by glucose oxidase method, HbA1 。 was tested by high efficiency liquid chromatography, fasting C- peptide(FCP)and 2 hour postprandial C - peptide(2 hCP)levels by radio immunoassay, and BMD of lumbar(L2-L4)and left femoral neck by DXA. Results No difference in age was observed between the two groups(P0.05). The study group was lower in BMI, WHR,FCP,2 hCP,and BMD of lumbar and left femoral neck, but higher in FPG