新诊断2型糖尿病患者血清内脂素与视黄醇结合蛋白4水平变化及其与胰岛素抵抗的关系.docVIP

· 1986 · · 论 著 · 新诊断2型糖尿病患者血清内脂素与视黄醇结合蛋白4水平 变化及其与胰岛素抵抗的关系 潘佳秋，王慧慧，田建武，刘丽娟 【摘要】 目的 探讨新诊断2型糖尿病 (T2DM) 患者血清内脂素 (Visfatin) 与视黄醇结合蛋白4 (RBP4) 表 达水平及其与胰岛素抵抗 (IR) 的关系。方法 选取新诊断 T2DM 患者78例 (T2DM 组)及健康体检者30例 (NC 组)。检测两组空腹血清Visfatin和 RBP4 水平，并计算其胰岛素抵抗指数 (HOMA-IR)、 胰岛β细胞功能指数 (HO- MA- β)、 胰岛素敏感性 (ISI), 对Visfatin、RBP4 及其他因素进行单因素相关分析，然后进行多元逐步回归分析。结 果 (1) T2DM 组患者血清Visfatin 〔(31 .0±12.5)ng/ml〕 和 RBP4〔(15.3±2.9)ng/ml〕 水平显著高于NC 组 〔(13.3±7.6)ng/ml,(11.4±1.7)ng/ml〕, 差异有统计学意义 (P0.01)。(2) 单因素相关分析显示，血清 Visfa- tin和RBP4 均与体质指数、三酰甘油 (TG)、 总胆固醇 (TC)、 空腹血糖 (FPG)、HOMA-IR 呈正相关 (P0.05); 与 HOMA- β、ISI 呈负相关 (P0.01);Visfatin 与 RBP4 呈正相关 (P0.01)。(3) 多元逐步回归分析发现， Visfa- tin 、TG和 FPG 为影响 RBP4 的最显著因素，常数项为零； RBP4 为影响 Visfatin 最显著因素，常数项为0.335。 结论 T2DM 患者血清Visfatin、RBP4 均显著升高，且二者呈正相关； Visfatin 水平高表达除类胰岛素样作用外还可能与胰岛β 细胞功能有关， RBP4 水平升高可能参与了IR 及 T2DM 的发生、发展。 【关键词】 内脂素；视黄醇结合蛋白4;胰岛素抵抗；糖尿病，2型 【中图分类号】 R587.1 【文献标识码】 A 【文章编号】1007-9572(2010)6C-1986-03 Relationship of Serum Visfatin to Retinol-binding Protein 4 level and to Insulin Resistance in Newly -diagnosed T2DM Patients PAN Jia-qiu, WANG Hui-hui, TIAN Jian-wu, et al. Department of Endocrinology, the First Affiliated Hospital of Jiamusi University,Jiamusi 154002,China 【Abstract] Objective To explore the relationship of serum visfatin to retinol -binding protein 4(RBP4)expression and to insulin resistance(IR)in newly -diagnosed type 2 diabetes mellitus(T2DM) patients. Methods Seventy -eight newly -diagnosed T2DM patients were divided into groups T2DM, control(healthy subjects). The fasting serum visfatin and RBP4 levels were determined; insulin resistance index(HOMA-IR),pancreatic β cell function index(HOMA-β), insulin sensi- tivity index(ISI) were calculated; univariate analysis was performed on visfatin, RBP4 and other factors, and then multiple re- gression analysis. Results The levels of serum visfatin and RBP4 were significantly higher in T2DM group(31.0±12.5ng/ml, 15.3±2.9 ng/ml,respectively