新诊断2型糖尿病患者血清视黄醇结合蛋白4和游离脂肪酸水平变化及其与胰岛素敏感性的关系研究.docVIP

·2370 · · 论 著 · 新诊断2型糖尿病患者血清视黄醇结合蛋白4和游离脂肪酸 水平变化及其与胰岛素敏感性的关系研究 潘佳秋，王慧慧，张超，于学静，姜飞飞 【摘要】 目的 探讨新诊断2型糖尿病 (T2DM) 患者血清视黄醇结合蛋白4 (RBP4) 和游离脂肪酸 (FFA) 的表达水平以及二者与胰岛素敏感性的关系。方法 选取新诊断 T2DM 患者76例 (T2DM 组)及健康体检者30例 (对照组)。观察各组空腹血清 RBP4 和 FFA 水平，并计算胰岛素抵抗指数 (HOMA-IR)、 胰岛素敏感性指数 (ISI) 用以评价各组胰岛素敏感性。结果 (1) T2DM 组患者血清 RBP4 和 FFA 水平显著高于对照组 (P0.01)。(2) 单 因素相关分析显示，血清RBP4 与体质指数 (BMI)、 三酰甘油 (TG)、 总胆固醇 (TC)、HOMA-IR、FFA 呈正相关， 与ISI、HOMA- β 呈负相关 (P0.05)。(3) 多元逐步回归分析发现， HOMA-IR、FFA 作为独立危险因素影响血清 RBP4 水平，常数项为零。 结论 T2DM 患者血清 RBP4 、FFA水平均显著升高； RBP4 水平升高与糖脂代谢有关，从而 导致胰岛素抵抗，进而参与T2DM 的发生、发展。 RBP4 与 FFA 在胰岛素抵抗中可能起协同作用。 【关键词】 糖尿病，2型；视黄醇结合蛋白4;脂肪酸，非酯化；胰岛素敏感性指数 【中图分类号】 R587.1 【文献标识码】 A 【文章编号】1007-9572(2011)07-2370-03 Changes of Serum Retinol Binding Protein 4 and Free Fatty Acids Levels among Newly Diagnosed Type 2 Diabetic Patients and the Correlations with Insulin-sensitivity PAN Jia-qiu, WANG Hui-hui,ZHANG Chao, et al. Department of Endocrinology, the First Affiliated Hospital of Jiamusi University,Jiamusi 154002,China 【Abstract 】 Objective To explore the levels of serum retinol binding protein 4(RBP4)and free fatty acids(FFA), as well as the relationships between RBP4 level, FFA level and insulin - resistance index(ISI)in newly diagnosed type 2 dia- betic patients. Methods Both Newly diagnosed type 2 diabetes patients(T2DM,n=76)and healthy subjects(NC,n=30) were enrolled grouping this study, with their serum levels of RBP4 and FFA measured. Also, insulin resistance index(HOMA- IR)and insulin sensitivity(ISI) were calculated in both groups. Results (1) Serum levels of RBP4 and FFA in the T2DM group were significantly higher than in the control group(P0.01).(2)Single -factor correlation analysis showed that ser- um RBP4 was positively correlated with BMI, triglyceride(TG), cholesterol(TC),HOMA-IR and FFA and negatively cor- related with ISI and HOMA-β(P0.05).(3)Multielement stepwise regression analysis discoveryed that