儿童肾母细胞瘤合并肺转移的临床特点和治疗.pdfVIP

现代肿瘤医学 2015年 o2月 第 23卷第 3期 MODERNONCOLOGY，Feb．2015，VOL．23，NO．03 ·415 · 儿 童 肿 瘤 专 儿童肾母细胞瘤合并肺转移的临床特点和治疗 张大伟 ，金 眉 ，周春菊 ，马晓莉 Clinicalcharacteristicsandtreatmentinchildrenwilmstumorwithpulmonarymetastasis ZhangDawei，JinMei，ZhouChunju，MaXiaoli HematologyCenter；DepartmentofPathology。CapitalUniversityofMedicalSciencesAffiliatedBeijingChildren Hospital，Being 100045，China． 【Abstract】 Objective：ToinvestigatetheclinicalcharacteristicsandtreatmentofchildrentumorWilmswithpul— monarymetastases．M ethods：Retrospectivena alysisofclinicalfeatures and treatmentexperience of10 children WilmstumorwithpulmonarymetastasisinDepartmentofHematologyCenterofBeijingChildren~HospitalBloodDis- easeCenterwasperformed．Results：3patientswereyoungerthan4yearsold．Themedianageatdiagnosedwas 5．5， theyoungestagewas3month．theoldestage11years．Shorttimetodiagnosiswas10day，large—timetodiagnosis was7years．Clinicalsymptomsincludedabdominalmassin8cases(80％)，hematuriain2cases(20％)，coughnad sputumin6cases(60％)，feverin2cases(20％)．Imaging：Assessmentexaminationweredoneinallpatients．B— ultrasound．Leftrenalinvolvementinsixcases(60％)，rightrenalinvolvementintwocases(20％)，renalsinvolve— mentintwocases(20％)，ChestCTshowedlungnodules，twocasesofchildrenwithunilaterallunginvolvement；lung noduleswerefoundineightcases．includingtwocasesofchildrenwithpleuraleffusion．Clinicalstage：3patientsre— lapsed，firstdiagnosedwithstageIonecase(10％)，stageⅡ，2cases(20％)，theremainingsevenpatientswerediag— nosedforthefirsttime，5cases(50％)ofstage1V，2eases(20％)ofstageV．Pathologictype：5casesofgemr ，2ca— sesofomesenchymal，1easeofepithelial type，2casesofmixedtype．TreatmentTumorwereresectedin10patients， accordingtoCOG —Ichemotherapy，onepatientlostduringtwocoursesofchemotherapy，sevenpatientsreceivedgood effects．apatientgaveup treatment6 monthslater．Conclusion：Children Wilmstumo