阿托伐他汀对急性脑梗死患者血清超敏C反应蛋白及白细胞介素－6的影响.pdfVIP

· 50 · 2011年7月第38卷第 14期 ChineseJournalofPracticaIMedicineJuly20lI，Vo1．38，No．14 阿托伐他汀对急性脑梗死患者血清超敏 C反应蛋 白及 白细胞介素 一6的影响 樊淑敏 【摘要】 目的 探讨阿托伐他汀对急性脑梗死(ACI)患者血清超敏c反应蛋白(hs—CRP)及白细胞介素一6 (IL一6)水平以及神经功能的影响。方法 将80例ACI患者随机分为阿托伐他汀组 (40例)和常规治疗组 (40 例)。阿托伐他汀组在常规治疗基础上加用阿托伐他汀20mg，每 日1次，连续服用4周。检测治疗前后血清 — CRP和 IL一6水平，并进行神经功能缺损程度评分 (NDS)评定。并以20例健康体检者作为正常对照组。结果 ACI患者血清hs—CRP和 IL一6水平较正常对照组明显升高(P 0．05)；治疗后两组血清hs—CRP和 lI一6水平 均较治疗前明显下降(均P0．05)，且阿托伐他汀组较常规治疗组下降明显 (P0．05)；两组NDS评分较治疗前 明显下降(均P0．05)，且阿托伐他汀组较常规治疗组下降明显 (P0．05)。结论 阿托伐他汀能明显降低ACI 患者血清hs—CRP和 II一6水平，并有助于ACI患者的神经功能恢复。 【关键词】 阿托伐他汀；脑梗死；超敏c反应蛋白；白细胞介素一6 Effectofatorvastatinonthelevelofserum high——sensitivityC ——reactiveproteinandinterleukin—— 6inpatientswithacutecerebralinfarction FANShu—rain．DepartmentofNeurology，theTradi— tionalChineseMedicalHospitalofYuncheng，Yuncheng274700，China 【Abstract】 Objective Toexploretheeffectofatorvastatinonthelevelofserumhighsensitivity C—reactiveprotein(hs—CRP)andinterleukin一6(IL一6)inpatientswithacutecerebralinfarction (ACI)．Methods EightypatientswithAC1wererandomlydividedintotheatorvastatintherapygroup (n=40)andtheconventionaltherapygroup(n=40)．Atthebasicofconventionaltherapy，theatolw— astatintherapygroupwastreatedwithatorvastatin20 mg／d．Bothgroupsweretreatedfor4weeks．The levelsofserumhs—CRPandIL一6weremeasuredandthescoresofneurologicaldeficit(NDS)weree— valuatedbeofreandaftertreatment．A healthycontrolgroupwhichapproximatelymatchedtheexperimen— talgroupincluded20 cases．Results Thelevelsofserum hs—CRP andIL一6inbothtwogroupsafter 14dtreatmentweresignificantlylowerthanthosebeofretreatment(allP 0．05)，andthelevelofser— um hs——CRPand IL——6 in atorvastatin therapy group wassignificantly lowerthan thatinconventional therapygroup(P 0．05)．NDSofbothgroupsaftertreatmentwerelowerthanthosebeforetreatment (P 0．05)，andthescoresofatorvastatintherapygroupweresignificantlylowerthanthoseofCOllven— tionaltherapygroup (P 0．05)．Conclusions Atorvastatincansignific