Hyperbaric oxygen deficiency kanamycin cochlear deafness of succinate dehydrogenase.docVIP

 PAGE \* MERGEFORMAT 10 Hyperbaric oxygen deficiency kanamycin cochlear deafness of succinate dehydrogenase Of: Zhang Qin Wang Yonghua Wang Feng Luo Ju Song [Abstract] [Objective] hyperbaric oxygen (HBO kanamycin deafness on cochlear succinic dehydrogenase in guinea pig kidney mildew (SDH change. [Method] 30 male guinea pigs were randomly divided into 3 groups n = 10, respectively, the normal control group (normal group, kidney deafness model group (model group treated with hyperbaric oxygen deficiency deafness group (treatment group, the auditory brainstem response (ABR and SDH histochemical assays as an indicator. [Results] guinea pigs significantly increased ABR response threshold, the treatment group increased rate of ABR response threshold was significantly lower than the model group, the difference was statistically significant (P lt;0.05, the model group was at the mere mention SDH pale or disappear, were significantly damaged hair cells in the treatment group SDH change of extent of the damage of hair cells were significantly lower than the untreated group. [Conclusion] HBO can enhance the activity of SDH inner ear, and promote functional recovery of damaged cells on kanamycin deaf guinea pig kidney deficiency have a therapeutic effect. [Key Words] high-pressure oxygen, succinate dehydrogenase mold, kidney, deafness Abstract: [Objective] To observe the effect of hyperbaric oxygen (HBOon succinate dehydrogenase (SDHof kanamycin induced ototoxic cochlear hair cells in kidney deficiency guinea pig. [Methods] 30 healthy male guinea pigs were divided randomly into three groups: normal group, model group and therapy group, 10 in each group.Auditory brain stem response (ABRand SDH in the cochlear hair cells were taken as indexes. [Results] The thresholds of ABR of the guinea pigs in the model group rose markedly, while those of therapy group rose slightly.The difference was significant between two groups.The degree of hair cell lesion in the model