Applications and Nanotoxicity of Carbon Nanotubes and Graphene in Biomedicine英文文献资料.docVIP

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Applications and Nanotoxicity of Carbon Nanotubes and Graphene in Biomedicine英文文献资料.doc

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Applications and Nanotoxicity of Carbon Nanotubes and Graphene in Biomedicine英文文献资料

HindawiPublishingCorporation JournalofNanomaterials Volume2012,ArticleID315185,19pages doi:10.1155/2012/315185 ReviewArticle ApplicationsandNanotoxicityofCarbonNanotubesand GrapheneinBiomedicine CaitlinFisher,1,2AmandaE.Rider,1,2ZhaoJunHan,1,2ShaileshKumar, 1,2 IgorLevchenko,1,2andKostya(Ken)Ostrikov 1,2 1 PlasmaNanoscienceCentreAustralia(PNCA),CSIROMaterialsScienceandEngineering,P.O.Box218,Lind?eld, NSW2070,Australia 2 PlasmaNanoscienceatComplexSystems,SchoolofPhysics,TheUniversityofSydney,Sydney,NSW2006,Australia CorrespondenceshouldbeaddressedtoZhaoJunHan,zhaojun.han@csiro.au Received7March2012;Accepted29March2012 AcademicEditor:KrasimirVasilev Copyright?2012CaitlinFisheretal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttributionLicense, whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited. Owingtotheiruniquemechanical,electrical,optical,andthermalproperties,carbonnanostructuresincludingcarbonnanotubes andgraphenesshowgreatpromiseforadvancingthe?eldsofbiologyandmedicine.Manyreportshavedemonstratedthepromise ofthesecarbonnanostructuresandtheirhybridstructures(compositeswithpolymers,ceramics,andmetalnanoparticles,etc.)for avarietyofbiomedicalareasrangingfrombiosensing,drugdelivery,anddiagnostics,tocancertreatment,tissueengineering,and bioterrorismprevention.However,theissueofthesafetyandtoxicityofthesecarbonnanostructures,whichisvitaltotheiruseas diagnosticandtherapeutictoolsinbiomedical?elds,hasnotbeencompletelyresolved.Thispaperaimstoprovideasummaryof thefeaturesofcarbonnanotubeandgraphene-basedmaterialsandcurrentresearchprogressinbiomedicalapplications.Wealso highlightthecurrentopinionswithinthescienti?ccommunityonthetoxicityandsafetyofthesecarbonstructures. 1.Introduction robustnesstothesecarbonnanostructuresinbiologicallyrel- evantenvironments[18–22].However,theissueoftoxicity of CNTs and graphene in living biological systems, which is vital for the successful incorporation of these materi