口服与静注铁剂治疗血液透析患者肾性贫血的疗效比较.pdfVIP

中国基层医药2007年 11月第l4卷第 l1期 Chin J Prim Med Pharm，November 2007，Vol…14,No．11 ‘1823‘ 口服与静注铁剂治疗血液透析患者肾性贫血的 疗效比较 杨 莉 【摘要】 目的 比较静脉与口服补铁对接受促红索治疗的血液透析患者的疗效。方法 口服组给予琥 珀酸亚铁，每次200 mg每日3次，连续2个月；静脉组给予静脉输注右旋糖酐氢氧化铁，每次 100 mg，每周2 次，共 1O次。观察治疗前后血红蛋白(Hb)、红细胞比容(Hct)、血清铁蛋白(sF)及转铁蛋白饱和度(TsAT)的 变化。结果 静脉补铁组治疗后 Fib、Hct、SF及TSAT均较口服组明显升高(均尸0．01)。口服补铁组临床 有效率2O％，静脉补铁组临床有效率6O％。静脉补铁明显优于口服补铁。结论 静脉补铁可迅速改善贫血， 配合EPO治疗效果明显，从而减少输血，减少医疗费用，应优选。 【关键词】 肾透析；贫血；红细胞生成素；铁化合物 Comparative observation of effects of intravenous iron and oral iron for hemodialysis anemia in patients YANG Li．Department of Nephrology Anqing Firn People Hospital，Anqing，Anhui 246003，China 【Abstract】 Objective To compare of treatment effects of intravenous iron and oral iron on hemodialysis ane— mia in patients with erythropoietin．Methods The oral dosage of ferrous succinate was 200mg dose，3 times a day for 2 months．After washing out for 2 months．Then these patients were given intravenous iron dextran with a dosage of 100mg twice a week for 5 weeks．During the treatment，hemoglobin(Hb)，hematocrit(Hct)，serum ferritin(SF) and trasferrin saturation(TSAT)were monitored．Results The efficacy of oral iron was 20％，the efficacy of intra— venous iron was 60％．The Hb，HCt，SF and TSATS level increased obviously in the efficacy of intravenous iron，sta— tistical analysis showed a very significant difference(P0．01) Intravenous iron supplement was better than oral iron．Conclusion Intravenous iron might quickly improve anemia，the combination with erythropoietin had 311 obvi— OUS therapeutic effect，which could reduce the blood transfusion and medical expenses．Intravenous iron should be se— lected firstly． 【Key words】 Renal dialysis；Anemia；Erythropoietin；Iron compounds 肾性贫血是各种肾脏疾病晚期随着肾功能不断 300 g／L，同时转铁蛋白饱和度(TSAT)20％人选。 减退而出现的贫血，是一种多因素导致的复合性贫 共30例。男20例，女10例，平均年龄46．3岁。 血。其贫血的根本原因在于促红细胞生成素(促红 1．2 研究方法 素)缺乏或产生相对不足。随着人类重组红细胞生