中药大黄素治疗中重度牙周炎的临床观察.pdfVIP

El腔医学研究2008年6月第24卷第3期 305 中药大黄素治疗中重度牙周炎的临床观察 杨明华 李升。 肖健平 林楠 (1．南京大学医学院附属口腔医院牙周病科 江苏南京 210008；2．井冈山大学医学院口腔医学系) [摘要] 目的：评价中药大黄素局部治疗牙周炎的临床疗效。方法：将36例中、重度慢性牙周炎患者，随机分为龈 下刮治组(对照组)和大黄素+龈下刮治组(实验组)。记录两组治疗前后的临床牙周指数、龈沟液量及龈沟液IL 一 1p浓度。结果：两组治疗后临床牙周指数、龈沟液量和龈沟液IL一1p浓度与治疗前相比均有显著性差异(P 0．05，P0．O1)；实验组治疗后龈沟液IL一1B浓度明显降低，其抑制率为74．82％优于对照组。结论：中药大黄素 临床治疗牙周炎可行。 [关键词] 中药 大黄素 牙周炎 龈沟液 白介素1一B [中图分类号] R781．4 [文献标识码] A [文章编号] 1671—7651(2008)o3—0305—03 Clinical Observation of Emodin on the Treatment of Moderate to Severe Periodontitis． YANG 凡g—hua，LI Sheng，XIAO Jian～ping，et a1．Affiliated Stomatology Hospital，Medical School，Nanfing University，Nanjing 210008 [Abstract] Objective：To evaluate the therapeutic effect of Chinese traditional medicine emodin on periodontitis．Meth． ods：36 patients with moderate to severe periondotitis were recruited and randomly divided into two groups．Patients in one grouP were treated with only subgingival scaling(Control group)，patients in the other group were treated with emodin plus subgingival scaling(Experimental group)．Results：Clinical periodontal index，amount of gingival crevicular fluid and concentration of IL一1 p in gingival crevicular fluid were all significantly improved in both groups(P0．05，P0．01)． But the concentration of IL一1 B in Experimental group were obviously lower than Control group．The inhibit ratio was 74． 82％ ，Conclusion：It is applicable to use Chinese traditional medicine emodin in the treatment of periodontitis， [Key words] Chinese traditional medicine Emodin Periodontitis Gingival crevicular fluid IL一1 B 大黄素是中药大黄的主要有效成分，近年的药 服抗生素或免疫抑制剂。排除患有系统性疾病及吸 理学研究显示其有抑菌、抗炎及免疫调节作用…。 烟者。经初步筛选，将36例36个牙周位点纳入本 体外研究证实，中药大黄素对人牙周膜细胞无明显 实验中，前牙11个，后牙25个，其中男性20例，女 毒性，且能阻断内毒素对人牙周膜细胞的毒性 ]。 性16例，年龄35～60岁，平均44