双眼形觉剥夺成年大鼠视皮层可塑性与cspgs和tpa表达关系的研究-relationship between plasticity of visual cortex and expressions of cs pgs and tpa in adult rats with binocular form deprivation.docxVIP

主要英文缩写词表缩写BFD英文名称binocularformdeprivation中文名称或注释双眼形觉剥夺CSPGschondroitinsulphateproteoglycans硫酸软骨素蛋白多糖ECMextracellularmatrix细胞外基质FVEPflash-visualevokedpotential闪光视觉诱发电位GABAγ-aminobutyricacidγ-氨基丁酸MDmonoculardeprivation单眼剥夺NMDAN-methyl-D-aspartateN-甲基-D-天冬氨酸PBSPhosphatebufferedsaline磷酸盐缓冲液PFAparaformaldehyed多聚甲醛PNNsperineuronalnet神经元周围网络PVEPpatternvisualevokedpotential图形视觉诱发电位PWpostnatalweeks出生后周龄tPAtissue-typeplasminogenactivator组织型纤溶酶原激活剂VEPsvisualevokedpotentials视觉诱发电位ThevisualcortexplasticityandrelationshipbetweenCSPGsandtPAinadultvisualcortexafterBinocularformdeprivationAbstractAfterhumanandthemammalian’sborn,visualsystemregulatedtheconnectionofneuronsandstructuresofsynapticsaccordingtothevisualenvironment,whichiscalledthecriticalperiodofvisualcortexplasticity.Researchesinthepastshowedthatamblyopiacanbetreatedonlyinthiscriticalperiod.Presentresearchesshowedthatvisualplasticityintheadultisjustinhibitedbutnotdisappearedanditcanbe“reactivated”insomespecificconditions.In2002,PizzorussodegradedtheCSPGsinadultrats’visualcortexbyusingchABCenzymes,whichfirstsuccessfullyrecoveredadultrats’visualcortexplasticity,andraisedtheamblyopiceye’svisualacuitybydeprivatinginputsofthefelloweye.Thisstudyfirstconfirmedthattheplasticityofadultvisualcortexcanbe“reactivated”.Thereafter,somestudieswhichused10days’darkrearing、environmentenrichment、theantidepressantdrugsandreducingintracorticalinhibitioninadultratscanalsorecoveradultvisualcortexplasticity.OurresearchesinthepastfoundthatbinocularformdeprivationcaninhibitethedevelopmentofGABAcircuit,reducethestrengthofneuronsynapses’transmission,andregulatetheexpressionanddistributionofinhibitingandexcitingneurotransmitterreceptorsinadultvisualcortex.ResearcheshaveshowedthatmaturingofPNNsconstitutedbyCSPGscanpromotethematuringofGABAinhibitioncircuit,butdegradationofPNNscanreducetheinhibitionofGABAcircuit.Therefore,reducingofPNNsisoneofthewaystoturndowninhibitionofGABAcircuitandwhetheritcanalsobecausedbybinocularformdeprivation(BFD)isnotknown.TP