TGF―βSmad通路成员Smad7在鼻内翻性乳头状瘤中表达和意义.docVIP

TGF―βSmad通路成员Smad7在鼻内翻性乳头状瘤中表达和意义 　　【摘要】 目的：探究TGF-β/Smad通路成员Smad7在鼻内翻性乳头状瘤（nasal inverted papilloma，NIP）中的表达情况，并进一步分析其在该病发生发展中的意义。方法：收集NIP标本31例为NIP组，正常下鼻甲（IT）组织标本23例为IT组，鼻腔鳞状细胞癌（NSCC）标本23例为NSCC组。采用免疫组化SP法检测Smad7在上述三组中的表达情况。结果：Smad7在IT中的阳性表达率为13.04%，在NIP中的阳性表达率为48.39%，在NSCC中为86.96%，三组的阳性表达率比较，差异有统计学意义（ 字2=25.154，P=0.000）；NIP组和IT组比较，NIP组和NSCC组比较，IT组和NSCC组比较，差异均有统计学意义 　　（ 字2=7.422、8.613、25.130，P=0.006、0.003、0.000）。结论：TGF-β/Smad通路成员Smad7在鼻内翻性乳头状瘤的发生发展中起一定作用。 　　【关键词】 TGF-β/Smad； Smad7； 鼻内翻性乳头状瘤； 鼻腔鳞状细胞癌 　　Expression of Smad7 Which Is TGF-β/Smad Pathway Member in Nasal Inverted Papilloma and Its Significance/LIU Miaozheng，ZHAO Changtong，ZHANG Aihua.//Medical Innovation of China，2018，15（06）：028-031 　　【Abstract】 Objective：To explore the expression of TGF-β/Smad pathway member Smad7 in nasal inverted papilloma（NIP） and to further analyze its significance in the development of NIP.Method：31 cases of NIP were collected as NIP group，23 cases of normal inferior turbinate tissue as IT group，and 23 cases of nasal squamous cell carcinoma（NSCC） as NSCC group.Immunohistochemical SP method was used to detect the expression of Smad7 in the above three groups.Result：The positive expression rate of Smad7 in IT was 13.04%，in NIP was 48.39%，in NSCC was 86.96%，and there was statistically significant difference among them（字2=25.154，P=0.000）；comparison between NIP group and IT group，comparison between nip group and NSCC group，comparison between IT group and NSCC group，the differences were statistically significant（字2=7.422，8.613，25.130，P=0.006，0.003，0.000）.Conclusion：Smad7 in TGF-β/Smad pathway plays an important role in the development of NIP. 　　【Key words】 TGF-β/Smad； Smad7； Nasal inverted papilloma； Nasal squamous cell carcinoma 　　First-author’s address：Graduate Department of Jiamusi University，Jiamusi 154007，China 　　doi：10.3969/j.issn.1674-4985.2018.06.008 　　鼻?确?性乳头状瘤（nasal inverted papilloma，NIP）是最常见的鼻、鼻窦良性上皮性肿瘤，其具备恶性肿瘤特质，可出现不同程度的异质性，可伴发育不良、原位癌及鳞状细胞癌[1]。因其临床特殊性，故有学者将其归为交界性肿瘤。TG