中西医结合治疗肾性高血压临床研究.docVIP

中西医结合治疗肾性高血压的临床研究 　　[摘要] 目的 选择中西医治疗方案治疗肾性高血压,具体采用缬沙坦及黄芪注射液,并评价该治疗方案治疗肾性高血压的效果及安全性。方法 将71例肾性高血压患者随机分为两组,缬沙坦组和两药联用组,两组疗程均为8周。监测治疗前后治疗有效率、血压、肾功能相关生化等。结果 缬沙坦组治疗总有效率62.9%;两药联用组治疗总有效率75.0%。两组间具有显著性差异(P0.05)。在治疗后第4周时两组血压出现显著性差异(P0.05)。两组均无明显不良反应。结论 缬沙坦及黄芪注射液治疗肾性高血压安全有效,疗效优于单用缬沙坦。 　　[关键词] 缬沙坦; 黄芪注射液; 肾性高血压 　　[中图分类号] R544.14 [文献标识码] A [文章编号] 1673-9701(2010)07-32-03 　　 　　Combined Chinese and Western Medicine for Renal Hypertension:A Clini- cal Study 　　HE Hongjuan XU Xianji CHEN Kang 　　Department of Internal Medicine,the Staff and Worker Hospital of China National Offshore Oil Nanhai West Corporation,Zhanjiang 524057,China 　　 　　[Abstract] ObjectiveTo use valsartan and astragalus injection for renal hypertension and evaluate the curative efficacy and safety. Meth- odsWe divided 71 cases of renal hypertension randomly into valsartan group and two-drug combined group,and both groups were treated for 8 weeks. The efficiency of treatment,blood pressure,renal function related to biological and chemical indicators were detected. ResultsThe total effective rate of the two- drug combined group was 75.0%,higher than 62.95 of the valsartan group,with a significant difference between the two groups(P0.05). The blood pressure of the two- drug combined group was obviously improved compared with the valsartan group(P0.05). The BUN,Scr and 24h urine protein in both groups were significant improved after treatment(P0.05). The Scr and 24h urinary protein of the two-drug combined group were significantly lower than those of the valsartan group(P0.05). There were no obvious adverse reactions in both groups. Conclu- sionThe combined use of valsartan and astragalus injection is safe and effective in the treatment of renal hypertension. 　　[Key words]Valsartan; Astragalus injection; Renal hypertension 　　 　　高血压是肾脏病的主要临床表现之一,肾性高血压是主要的继发性高血压,但在各种不同的肾实质性疾病中,其发病机制不完全相同[1]。肾胜高血压的治疗目标为有效控制血压,延缓肾功能衰竭的进展,减少心脑血管并发症。但因其多难以控制,往往需要联合应用2种或以上的降压药物。我们在临床治疗应用中选择中西医治疗方案进行治疗,具体采用缬沙坦及黄芪注射液,并评价该治疗方案治疗肾性高血压的