利培酮与奥氮平治疗酒精所致精神和行为障碍临床研究.docVIP

利培酮与奥氮平治疗酒精所致精神和行为障碍临床研究 　　摘 要：目的 探讨利培酮和奥氮平对酒精所致精神和行为障碍的疗效及安全性。方法 选取2016年7月～2017年6月本院收集94例酒精所致精神和行为障碍患者，随机分为利培酮组和奥氮平组，各47例，分别给予利培酮和奥氮平治疗8周。用简明精神病评定量表（BPRS）评定疗效，治疗中出现的症?盍勘恚?TESS）评定不良反应。结果 两组完成8周的治疗，有效率、临床治愈率对比无差异，不存在统计学意义（P0.05）。不良反应中锥体外系反应（EPS）利培酮组高于奥氮平组，过度镇静奥氮平组高于利培酮组，具有统计学意义（P0.05），其余不良反应无差异。结论 利培酮与奥氮平治疗酒精所致精神和行为障碍疗效相似，但奥氮平过度镇静的不良反应更明显，利培酮锥体外系反应的不良反应也不容忽视。 　　关键词：酒精所致精神和行为障碍；奥氮平；利培酮 　　中图分类号：R749.62 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.03.048 　　文章编号：1006-1959（2018）03-0137-03 　　Abstract：Objective To investigate the efficacy and safety of risperidone and olanzapine in the treatment of alcohol-induced mental and behavioral disorders.Methods 94 patients with mental and behavioral disorders induced by alcohol were collected from July 2016 to June 2017.They were randomly divided into risperidone group（n=47）and olanzapine group（n=47）.They were treated with risperidone and olanzapine for 8 weeks respectively.The efficacy was evaluated by（BPRS），and adverse reactions were assessed by symptom scale（TESS）.Results There was no difference in the effective rate and the clinical cure rate between the two groups after 8 weeks of treatment.There was no statistical significance（P0.05）.Extrapyramidal response（EPS）was higher in risperidone group than in olanzapine group，and the excessive sedation of olanzapine group was higher than that of risperidone group，with statistical significance（P0.05），the remaining adverse reactions no difference.Conclusion Risperidone is similar to olanzapine in the treatment of alcohol-induced mental and behavioral disorders.However，the adverse effects of olanzapine over sedation were more obvious，and those of risperidone extrapyramidal reaction could not be ignored. 　　Key words：Alcohol induced mental and behavioral disorders；Olanzapine；Risperidone 　　酒精所致精神和行为障碍包括酒精所致的幻觉症、酒精所致的嫉妒妄想、科萨科夫精神病、Wernicke病或Wernicke脑病、酒精所致的痴呆、酒精所致的心境障碍[1]。利培酮和奥氮平均属于第二代抗精神病药物。精神科治疗精神病性症状时两种药物在均作为首选，选取2016年7月～2017年6月在我院物质依赖病房住院患者，以两种药治疗酒精所致精神和行为障碍，对治疗效果和药物不良反应，报告如下。 　　1资料