呼吸道感染患儿血清肌酸激酶同工酶和羟丁酸脱氢酶改变及临床意义.docVIP

呼吸道感染患儿血清肌酸激酶同工酶和羟丁酸脱氢酶改变及临床意义 　　[摘要] 目的：探讨呼吸道感染患儿血清肌酸激酶同工酶（CK-MB）和羟丁酸脱氢酶（HBDH）的改变及临床价值。方法：采用免疫抑制法分别测定94例呼吸道感染患儿和100例健康儿血清CK-MB和HBDH水平。结果：呼吸道感染组患儿血清CK-MB和HBDH水平与正常对照组比较明显升高，相比较差异有统计学意义（P0.05）；血清CK-MB和HBDH水平随着感染程度加重而升高，CK-MB、HBDH与感染程度呈正相关（r=0.518，0.527，P0.01）。结论：联合监测CK-MB和HBDH有助于判断呼吸道感染患儿的病情严重程度。 　　[关键词] 肌酸激酶同工酶 羟丁酸脱氢酶 呼吸道感染 小儿 　　[中图分类号] R446.11[文献标识码] B [文章编号] 1673-7210（2011）02（b）-058-02 　　Variation and clinical significance of serum CK-MB and HBDH in children with respiratory infections 　　XIAO Jin1, WANG Lijun1, LI Jianqing2 　　(1.Clinical Laboratory, Zhangmutou Hospital of Dongguan City, Guangdong Province, Dongguan 523633,China; 2. Department of Paediatrics, Zhangmutou hospital of Dongguan City, Guangdong Province, Dongguan 523633,China) 　　[Abstract] Objective: To explore the variation and clinical significance of serum CK-MB and HBDH in children with respiratory infections. Methods:94 cases of children with respiratory infections (respiratory infections group) and 100 healthy children (control group) were studied, the serum CK-MB and HBDH levels were detected using immunosuppression methods. Results: The serum CK-MB and HBDH levels of the respiratory infections group were higher than the control group, compared difference was significant (P0.05); the serum CK-MB and HBDH levels increased with increasing degrees of infections,the different degrees of infections were positively correlated with CK-MB and HBDH levels (r=0.518，0.527，P0.01). Conclusion: Combined monitoring of serum CK-MB and HBDH of children with respiratory infections can help determine the extent of infections. 　　[Key words] CK-MB; HBDH; respiratory infections; children 　　 　　呼吸道感染按病情的轻重程度可以分为上呼吸道感染、肺炎和肺炎心衰三种类型，呼吸道感染是小儿常见疾病，是发病率高、危害性大的病毒性传染病之一。病情进展至重症肺炎时，可以并发心力衰竭，这是我国小儿死亡的重要原因[1]。由于呼吸道感染患儿常常合并心肌损伤，它成为影响患儿治愈率和病死率的关键因素。因此，寻找诊断小儿呼吸道感染对心肌损害的敏感性生化指标一直是研究的热点。肌酸激酶同工酶（CK-MB）和羟丁酸脱氢酶（HBDH）作为心肌损伤的标志物备受关注。我们通过检测呼吸道感染患儿血清CK-MB和HBDH的水平，观察血清CK-MB、HBDH水平与病情严重程度的关系，为小儿呼吸道感染的诊断和治疗提供理论参考。 　　 　　1 资料与方法