对比两种不同药物治疗老年原发性三叉神经痛患者疗效和对睡眠质量影响.docVIP

对比两种不同药物治疗老年原发性三叉神经痛患者疗效和对睡眠质量影响 　　【摘要】 目的 观察拉莫三嗪与卡马西平治疗老年原发性三叉神经痛患者临床疗效以及对睡眠质量的影响。方法 72例原发性老年三叉神经痛患者， 根据随机数字表法分为实验组和对照组， 每组36例。实验组口服拉莫三嗪， 对照组口服卡马西平。观察两组患者的临床治疗疗效、不良反应发生率以及睡眠质量评分。结果 实验组显效23例、有效10例、无效3例；对照组显效14例、有效10例、无效12例， 实验组的治疗总有效率为91.67%， 显著高于对照组的66.67%， 差异具有统计学意义（χ2=6.821， P0.05）。上述不良反应均未做特殊处理， 后患者自行缓解。结论 拉莫三嗪治疗老年原发性三叉神经痛近期疗效显著， 安全性高， 且有利于老年患者的睡眠， 值得临床推广。 　　【关键词】 原发性三叉神经痛；卡马西平；拉莫三嗪；疼痛；睡眠质量 　　DOI：10.14163/j.cnki.11-5547/r.2016.32.060 　　【Abstract】 Objective To observe clinical effects by lamotrigine and carbamazepine in the treatment of senile primary trigeminal neuralgia patients and their influence on quality of sleep. Methods A total of 72 senile primary trigeminal neuralgia patients were divided by random number table into experimental group and control group， with 36 cases in each group. The experimental group received oral administration of lamotrigine， and the control group received carbamazepine instead. Observation was made on clinical effect， incidence of adverse reactions and quality of sleep score in both groups. Results The experimental group had 23 excellent cases， 10 effective cases， and 3 ineffective cases， and the control group had 14 excellent cases， 10 effective cases， and 12 ineffective cases. The experimental group had much higher total effective rate as 91.67% than 66.67% in the control group， and the difference had statistical significance （χ2=6.821， P0.05）. All mentioned adverse reactions relieved without specific treatment. Conclusion Lamotrigine shows excellent short-term effect and high safety in treating senile primary trigeminal neuralgia， and it is beneficial for sleep in senile patients. It is worth clinical promoting. 　　【Key words】 Primary trigeminal neuralgia； Carbamazepine； Lamotrigine； Pain； Quality of sleep 　　原?l性三叉神经痛是一种以间歇痛为主要临床表现的较为常见的神经系统疾病， 其疼痛的主要区域为第五对颅神经的分布区域[1]。一旦发生三叉神经痛这种强烈的不适感会严重影响患者的睡眠， 而严重的睡眠障碍会导致抑郁现象的发生， 目前临床上主要以药物治疗进行干预， 来缓解患者病情[2]。目前随着新一代抗癫痫药物拉莫三嗪的问世， 虽然其有被应用于三叉神经痛的临床研究中， 但目前国内尚未有该种药物对于老年原发性三叉神经痛患者治疗有效率以及对