思密达抑制红霉素产生胃肠道不良反应疗效评价.docVIP

思密达抑制红霉素产生胃肠道不良反应疗效评价 　　[摘要] 目的 探讨思密达在红霉素注射过程中对所产生的胃肠道不良反应的抑制效果。 方法 将临床确诊的110例呼吸道感染疾病患者分为两组，每组平均55例。对A组患者采用单独注射红霉素的方法进行治疗；B组患者采用先静脉注射思密达后静脉注射红霉素的方法进行治疗。对两组患者在治疗过程中出现的各种并发症和不良反应现象的人数进行比较分析。 结果 分析结果表明，恶心、呕吐、腹痛、腹泻是患者在治疗过程中出现的主要并发症和不良反应，B组患者出现并发症和不良反应的人数明显少于A组患者，有显著的统计学差异（P 0.05）。结论 在采用静脉注射红霉素对患者进行治疗之前冲服思密达，可对患者由于注射红霉素所产生的胃肠道不良反应起到很好的抑制效果，可以做为今后临床对该类患者进行治疗的首选方法。 　　[关键词] 思密达；红霉素；胃肠道不良反应 　　[中图分类号] R595.3[文献标识码] B[文章编号] 1673-9701（2012）10-0147-02 　　Inhibition of erythromycin in the gastrointestinal adverse effect evaluation 　　YIN Zhi 　　Department of Pharmacy， the Peoples Hospital of Gaochun County in Jiangsu Province， Gaochun 211300, China 　　[Abstract] Objective To investigate the secret of thought in erythromycin injection process to the gastrointestinal side effects produced by the inhibition effect. Methods One hundred and ten patients with clinically diagnosed were divided into two groups， the average every group of 55 patients. A group of patients using A separate injection erythromycin method for treatment. B group of patients be treated with intravenous Smecta firstly， followed by intravenous erythromycin. Comparative analysis of two groups complications arise in the treatment and the number of adverse phenomena. Results The analysis showed that appeared during treatment in patients with major complications and adverse phenomenon is nausea， vomiting， abdominal pain， diarrhea. Group B， complications and adverse reactions was significantly less than the number of phenomena in group A. It has a significant statistical difference （P 0.05）. Conclusion The use of intravenous erythromycin in the treatment of patients before， blunt Smecta allows injection of erythromycin to patients because of gastrointestinal adverse reactions play a very good inhibitory effect of the phenomenon. It can be used as a first method for future clinical treatment. 　　[Key words]Smecta； Erythromycin； Gastrointestinal adverse reaction 　　红霉素是一种广谱抗生素类药物，目前被用来治疗各种呼吸道感染性疾病，尤其适用于那些对青霉素有过敏史和耐