急性呼吸困难患者血浆N―末端脑钠肽水平及其与心功能相关性分析.docVIP

急性呼吸困难患者血浆N―末端脑钠肽水平及其与心功能相关性分析 　　[摘要] 目的 探讨急性呼吸困难患者血浆Nt-proBNP水平及其与心功能的相关性。 方法 选取本院2011年10月～2013年12月诊治的急性呼吸困难患者116例，其中肺源性呼吸困难患者58例为A组，心源性呼吸困难患者58例为B组。健康体检人员58例为对照组，均行Nt-proBNP检测和心功能检查。分析Nt-proBNP与心功能相关指标的相关性。 结果 A组患者Nt-proBNP、LVEDD、LVESD均明显高于对照组，而LVEF、6min步行距离、SDNN、SDNNI、SDANN、RMSSD、PNN50均明显低于对照组。B组患者Nt-proBNP、LVEDD、LVESD均明显高于对照组和A组，而LVEF、6min步行距离、SDNN、SDNNI、SDANN、RMSSD、PNN50均明显低于对照组和A组（P0.05）。Nt-proBNP与LVEF、6min步行距离、SDNN、SDNNI、SDANN、RMSSD、PNN50均呈负相关，与LVEDD、LVESD、心功能分级均呈正相关。 结论 急性呼吸困难患者血浆Nt-proBNP显著升高，心源性呼吸困难患者升高幅度更大。Nt-proBNP与心功能指标存在明显的相关性。 　　[关键词] 呼吸困难；N-末端脑钠肽；心功能；相关性 　　[中图分类号] R541.6 [文献标识码] A [文章编号] 2095-0616（2014）24-30-04 　　Correlation analysis of heart function and plasma Nt-proBNP in patients with acute dyspnea 　　LI Qiaoyan 　　Department 2 of Circulation，Peoples Hospital of Xingcheng City，Liaoning Province，Xingcheng 125100，China 　　[Abstract] Objective To investigate correlation of heart function and plasma Nt-proBNP in patients with acute dyspnea. Methods 116 patients with acute dyspnea were selected in hospital from October 2011 to December 2013.58 patients were pulmonary dyspnea as group A.58 patients were cardiac dyspnea as group B.58 health physical examination people as control group.All people treated Nt-proBNP detection and heart function examination.Correlation of Nt-proBNP and heart function related index was analyzed. Results Nt-proBNP，LVEDD，LVESD in group A were significantly higher than control group.LVEF，6min walking distance，SDNN，SDNNI，SDANN，RMSSD，PNN50 in group A were significantly lower than control group.Nt-proBNP，LVEDD，LVESD in group B were significantly higher than control group and group A.LVEF，6min walking distance，SDNN，SDNNI，SDANN，RMSSD，PNN50 in group B were significantly lower than control group and group A（P0.05）.Nt-proBNP had significant negative correlation with LVEF，6min walking distance SDNN，SDNNI，SDANN，RMSSD，PNN50.Nt-proBNP had significant positive correlation with LVEDD，LVESD classification of cardiac function. Conclusion