新风胶囊对干燥综合征肺功能影响及其机制研究.docVIP

新风胶囊对干燥综合征肺功能影响及其机制研究 　　【摘 要】目的：观察新风胶囊对干燥综合征患者肺功能的影响，并探讨其作用机制。方法：将 　　40例干燥综合征患者随机分为治疗组和对照组，每组20例。治疗组给予新风胶囊每次1.5 g，每日3次，口 　　服;对照组给予白芍总苷胶囊每次0.6 g，每日3次，口服。两组疗程均为1个月，观察两组患者临床疗效及治疗前后肺功能、中医症状积分、实验室指标等的变化。结果：治疗组临床治愈5例，显效7例，有效 　　6例，无效2例，总有效率为90.00%;对照组临床治愈3例，显效4例，有效7例，无效6例，总有效率为70.00%。两组比较，差异有统计学意义（P lt; 0.05）。治疗组MVV、IC、PEF、FEF25、FEF50均明显升高（P lt; 0.05或P lt; 0.01），对照组FVC、MVV明显升高（P lt; 0.05或P lt; 0.01）。其中，治疗组MVV较对照组改善程度更显著，治疗组PEF、FEF25、FEF50、FEF75的均值均显著高于对照组（P lt; 0.05或 　　P lt; 0.01）。在实验室指标、中医症状积分等方面比较，治疗组优于对照组（P lt; 0.05）。结论：新风胶囊对干燥综合征具有很好的临床疗效，能明显改善患者的肺功能、中医症状积分及实验室指标。 　　【关键词】 干燥综合征;肺功能;新风胶囊 　　doi：10.3969/j.issn.2095-4174.2015.01.003 　　Study on the Effects of Xinfeng Capsule on Pulmonary Function of Patients with Sj?grens Syndrome and Its Mechanism 　　FAN Hai-xia，LIU Jian，HUANG Chuan-bing，SHEN Xi，WANG Yuan，WANG Gui-zhen，YANG Jia 　　【ABSTRACT】 Objective：To observe the effects of Xinfeng Capsule（新风胶囊）on pulmonary function of patients with sj?grens syndrome，and to explore its mechanism of action.Methods：40 cases of Sj?grens syndrome were randomly divided into a treatment group and a control group，20 cases in each.The treatment group was orally given Xinfeng capsules，1.5 g of each time，3 times daily; while the control group was orally given Total Glucosides of Paeony Capsules （白芍总苷胶囊），0.6 g of each time，3 times a day.The two groups were treated for 1 month，observing the clinical curative effect and the changes of pulmonary function，TCM symptom score and laboratory indicators of the two groups before and after treatment.Results：In the treatment group，5 cases were cured，7 cases were markedly effective，6 cases were effective，and 2 cases were invalid，the total efficiency being 90%; while in the control group 3 cases were cured，4 cases were markedly effective，7 cases were effective，and 　　6 cases were invalid，the total efficiency being 70%.The difference between the two groups was statistically significant（P lt; 0.05）.The MVV，IC，PEF，FEF25 and FEF50 of the treatment group si