腹腔循环热灌注联合化疗治疗晚期胃癌合并腹腔积液有效性和安全性分析.docVIP

腹腔循环热灌注联合化疗治疗晚期胃癌合并腹腔积液有效性和安全性分析 　　【摘要】 目的 探索腹腔循环热灌注联合化疗在治疗晚期胃癌合并腹腔积液中的有效性和安全性。方法 96例晚期胃癌合并腹腔积液患者， 随机分为对照组和观察组， 每组48例。对照组患者单一采用化疗治疗， 观察组患者给予腹腔循环热灌注联合化疗治疗。对比两组患者的治疗效果。结果 观察组患者的治疗有效率为62.50%， 高于对照组的41.67%， 差异具有统计学意义（P0.05）。观察组患者不良反应发生率为20.83%， 低于对照组的39.58%， 差异具有统计学意义（P0.05）。结论 腹腔循环热灌注联合化疗治疗晚期胃癌合并腹腔积液效果确切， 且安全性高， 有助于提高患者的生存质量， 值得推广。 　　【关键词】 腹腔循环热灌注；化疗；晚期胃癌；腹腔积液；临床疗效；不良反应 　　DOI：10.14163/j.cnki.11-5547/r.2017.13.047 　　【Abstract】 Objective To explore the efficacy and safety of abdominal circulating hot perfusion combined with chemotherapy in the treatment of advanced gastric cancer complicated with hydrops abdominis. Methods A total of 96 advanced gastric cancer complicated with hydrops abdominis patients were randomly divided into control group and observation group， with 48 cases in each group. The control group received simple chemotherapy for treatment， and the observation group received abdominal circulating hot perfusion combined with chemotherapy for treatment. Therapeutic effect was compared in two groups. Results The observation group had higher total treatment effective rate as 62.50% than 41.67% in the control group， and the difference had statistical significance （P0.05）. The observation group had lower incidence of adverse reactions as 20.83% than 39.58% in the control group， and the difference had statistical significance （P0.05）. Conclusion Combination of abdominal circulating hot perfusion and chemotherapy shows affirmative effect in treating advanced gastric cancer with high safety， and it helps to improve quality of life in patients. So it is worthy of promotion. 　　【Key words】 Abdominal circulating hot perfusion； Chemotherapy； Advanced gastric cancer； Hydrops abdominis； Clinical curative effect； Adverse reactions 　　胃癌是常?的恶性肿瘤， 发病率高， 晚期胃癌患者肿瘤细胞扩散???腹腔很容易引起腹腔积液， 一旦引发腹腔积液， 将会直接影响到治疗效果， 影响到患者的生存质量[1， 2]。本院对晚期胃癌合并腹腔积液患者采用腹腔循环热灌注联合化疗治疗， 取得满意的治疗效果， 现报告如下。 　　1 资料与方法 　　1. 1 一般资料 本研究中的96例患者为2014年6月～2016年6月本院收治的晚期胃癌合并腹腔积液患者， 患者均经彩超、病理细胞学检查予以确诊， 预计生存期超过3个月。排