高雄激素血症患者糖脂代谢研究进展.docVIP

高雄激素血症患者糖脂代谢研究进展 　　[摘要] 在正常月经周期的卵泡期，血清睾酮浓度超过正常参考范围即形成高睾酮血症或者高雄激素血症。高雄激素血症患者常会产生胰岛素抵抗或糖脂代谢的异常，高雄激素血症患者糖脂代谢异常以超重肥胖型患者最为明显，甘油三酯是高雄激素血症患者最早表现异常的血脂指标。研究高雄激素血症与糖脂代谢的相关性，可对高雄激素血症代谢异常患者实施生活方式和药物治疗的指导，高雄激素血症患者应调整好自身的生活方式，适当地进行有氧运动，还可以根据临床症状的严重程度使用一些药物治疗，以此改善生活质量，预防心脑血管疾病的发生。 　　[关键词] 雄激素；高雄激素血症；多囊卵巢综合征；糖代谢；脂代谢 　　[中图分类号] R711.75 [文献标识码] A [文章编号] 1673-9701（2017）10-0165-04 　　Research progress of glucose and lipid metabolism in patients with hyperandrogenism 　　XIONG Juan YANG Hao 　　Department of Laboratory， Hanchuan People s Hospital in Hubei Province， Hanchuan 431600， China 　　[Abstract] In the follicular phase of the normal menstrual cycle， the high testosteroneemia or hyperandrogenism is formed when the serum testosterone concentration exceeds the normal reference range. Patients with hyperandrogenism often have insulin resistance or abnormal glucose and lipid metabolism. Overweight and obese type patients are the most obvious in hyperandrogenism patients with abnormal glucose and lipid metabolism. Triglycerides is the earliest abnormal indicator of dyslipidemia in patients with hyperandrogenism. Study on the relationship between hyperlipidemia and glucose， lipid metabolism can guide the implementation of lifestyle and drug therapy in patients with metabolic abnormalities of hyperandrogenism. Patients with hyperandrogenism should adjust their own way of life， and take appropriate aerobic exercise. They can also use some medications based on the severity of clinical symptoms in order to improve the quality of life and prevent cardiovascular and cerebrovascular disease. 　　[Key words] Androgen； Hyperandrogenism； Polycystic ovary syndrome； Glucose metabolism； Lipid metabolism 　　高雄激素血?Y即高睾酮血症，在正常月经周期的卵泡期，血清睾酮浓度平均为0.43 ng/mL，如超过0.7 ng/mL即称为高睾酮血症或者高雄激素血症。雄激素（androgen）属于固醇类荷尔蒙（steroid hormone），是含有19个碳（19 C）的甾体激素，种类包括硫酸脱氢表雄酮（dehydroepiandrosterone sulfate，DHEAS）、脱氢异雄酮（dehydroepiandrosterone，DHEA）、雄烯二酮（androstenedione）、睾酮（tes-tosterone，T）和二氢睾固酮（5α-dihydrotestosterone，DHT），上述几种激