二甲双胍对大鼠焦虑和恐惧行为的作用及机制-药理学专业论文.docxVIP

独创性声明 本人声明所呈交的学位论文是我个人在导师的指导下进行的研究工作及取得的 研究成果。据我所知，除文中已标明引用的内容外，本论文不包含任何其他人或集体 已经发表或撰写过的研究成果。对本文的研究做出贡献的个人和集体，均已在文中以 明确方式标明。本人完全意识到本声明的法律结果由本人承担。 学位论文作者签名： 日期： 年 月 日 学位论文版权使用授权书 本学位论文作者完全了解学校有关保留、使用学位论文的规定，即：学校有权保 留并向国家有关部门或机构送交论文的复印件和电子版，允许论文被查阅和借阅。本 人授权华中科技大学可以将本学位论文的全部或部分内容编入有关数据库进行检索， 可以采用影印、缩印或扫描等复制手段保存和汇编本学位论文。 保密□，在 年解密后适用本授权书。 本论文属于 不保密□√。 （请在以上方框内打“√”） 学位论文作者签名： 指导教师签名： 日期： 年 月 日 日期： 年 月 日 目录 缩略词表··························································································· 1 中文摘要··························································································· 2 Abstract 4 前 言······························································································ 7 第一部分 二甲双胍拮抗大鼠焦虑样行为的机制····································· 10 材料与方法················································································· 10 结果·························································································· 16 讨论·························································································· 22 小结·························································································· 24 第二部分 二甲双胍对大鼠线索型恐惧记忆消散的作用及机制··················· 25 材料和方法················································································· 25 结果·························································································· 27 讨论·························································································· 33 小结·························································································· 34 全文总结························································································· 35 本文创新点······················································································ 36 展望······························································································· 36 参考文献························································································· 37 综述························