焦虑泰康饮的成型工艺和质量标准的实验研究-药物分析学专业论文.docxVIP

黑龙江中医药人学硕十学何论文ABSTRACT 黑龙江中医药人学硕十学何论文 ABSTRACT Granula for antianxiety and tranquilizing consists of huanglian(Coptis chinensis Franch) huangqin(ScuteIlaria baicalensis Georgi)、 baishao(Paeonia Llactiflora Pall．)、 ej iao(Equus asinus L．)，and has the function of nourishing yin and heat-clearing，restoring normal coordination between heart and kidney，therapying anxiety disorders，relieving asthenic yin causing excessive pyrexia as well as upsetting and hyposomnia， and dry throat etc． Under the guidance of the theories of TCM，Granula for antianxiety and tranquilizing has been researched on pre—clinical pharmacy．Moulding conditions were screened．The technique of TLC was used to identify Coptis chinensis Franch，Scutetlaria baicalensis Georgi，Paeonia Llactiflora Pall．，The contents of berberine hydrochloride and baicalin were determined by HPLC． The quality standard was built up 0n the basis of TLC and HPLC． Results：the identification by TLC is fast and convenient；the effect is satisfying；the reproducibility is；steady；the specificity is good．Berberine hydrochloride showed good linear relationship in the range of O．033728～0．16864ug．The average recovery was 100．54％，RSD 1．54％．Baicalin showed good linear relationship in the range of 0．04976～0．2488ug．The average recovery was 99．98％，RSD 1．20％．The results can become the quantity index of qualify control on Granula for antianxiety and tranquilizing． Keywords：Granula for antianxiety and tranquilizing TLC HPLC Berberine hydrochloride Bajcalin 2 黑龙江中医药大学硕十学何论文引 黑龙江中医药大学硕十学何论文 引 言 1．选题目的、意义和立题依据 焦虑泰康饮是由黄连129、黄芩69、白芍69、阿胶99四味 药所制成的颗粒剂。功效滋阴清热，交通心肾，主要用以治由 阴虚火旺、五志过极、劳脑过度、心肾阴虚所致心肾不交型焦 虑症，心阴不足则心火过盛，肾阴不足则不能上济心火，证见 阴虚、火旺、不寐。少阴病阴虚阳亢不寐证，证中心烦不得卧， 伴见咽干口燥，舌绛少苔，脉细数等阴虚火旺证。可用于焦虑 症的治疗 。 随着现代生活节奏的加快，学习、就业、工作压力的增大， 竞争加剧，以及对自我期望值的增高，精神压力也随之增大。 社会经济快速发展的同时，人们的精神健康却呈现出与之相反 的状况，有资料表明，在精神障碍占全球疾病的总负担中，高 收入的国家约是低收入国家的2倍。进入二十一世纪，人们对 精神健康的关注，已从传统的重型精神障碍，如精神分裂症渐 向轻型精神障碍，如神经症转变。焦虑症在我国作为神经症的 一个亚型，越来越受到广大临床医务工作者的重视。在国外， 焦虑病人受到很大关注，所以十分重视抗焦虑药的开发。 焦虑症在人群中的