菜籽多肽改善小鼠睡眠功效的研究.pdfVIP

2017 年第 30 卷第 4 期 粮食与油脂 57 菜籽多肽改善小鼠睡眠功效的研究 王禹程，李云亮，杨　雪，马海乐 （江苏大学食品与生物工程学院，　江苏镇江　2 12013 ） 摘　要：研究菜籽多肽对改善小鼠睡眠功效的影响。试验组以2.5 g/kg ·BW ·d 剂量菜籽多肽灌胃 ICR 小鼠，对照组灌胃等体积蒸馏水，14 d 后进行直接睡眠试验、戊巴比妥钠阈下剂量催眠试验、巴 比妥钠睡眠潜伏期试验和延长戊巴比妥钠睡眠时间试验，同时记录小鼠体重和脏器指数用于观察 Ρ 小鼠及其脏器健康程度。结果表明：菜籽多肽有显著提高小鼠睡眠率（＜0.05 ）和显著延长睡眠 Ρ Ρ 时间（＜0.05 ）的作用，但没有缩短小鼠睡眠潜伏期的作用（＞0.05 ）。试验期间2 组小鼠体重和 脏器指数均没有差异。说明菜籽多肽可通过延长小鼠睡眠时间来改善睡眠。 关键词：菜籽；多肽；改善睡眠 Research of the effect of rapeseed peptides on improving mice slumber WANG Yu-cheng ，LI Yun-liang ，YANG Xue ，MA Hai-le （School of Food and Biology Engineering ，Jiangsu University ，Zhenjiang 212013 ，Jiangsu ，China ） Abstract ：The effect of rapeseed peptides on improving mice slumber were studied. Mice in test group were gavaged rapeseed peptides with dose of 2.5 g/kg ·BW ·d ，while control group gavaged with same volume of distilled water. 14 days later ，direct hypnosis experiment ，subthreshold dose of pentobarbital sodium hypnotic experiment ，barbital sodium sleep latency experiment and prolonged pentobarbital sodium sleep time experiment were conducted. Meanwhile，the body weight and organ index of mice were Ρ recorded. The result indicated that rapeseed peptides could significantly improve mice sleep rate （＜0.05 ） Ρ and significantly prolong the sleeping time of mice （＜0.05 ）. However rapeseed polypeptides did not have the effect of shortening sleep latency time. During the experiment period ，the body weight and organ index had no significant difference between control group and test group. The results showed that rapes