基础医学课件-概论.pptVIP

第六编药物治疗学基础 Section VIPharmacological basis of drug therapeutics General Principles General Concepts History The Nature of Drugs Methodology of Pharmacology New Drug Research and Development General Concepts Human disease: prevention and treatment Drug therapy Surgery Radiotherapy Physical therapy Psychological therapy 药理学是药物治疗学的基础理论 General Concepts Pharmacology can be defined as the study of substances that interact with living systems through chemical processes, especially by binding to regulatory molecules and activating or inhibiting normal body processes. Medical Pharmacology is often defined as the science of substances used to prevent, diagnose, and treat disease. － Katzung BG (Ed). Basic Clinical Pharmacology (11th Edition). New York: McGraw-Hill, 2010. 药理学是研究药物与机体（包括人体和病原体）相互作用的规律及其原理，是一门为临床合理用药防治疾病提供基本理论的医学基础学科。 What is Pharmacology studied? Pharmacodynamics（药效动力学，药效学）: the actions of the drug on the body and the mechanisms Pharmacokinetics（药代动力学，药动学）: the actions of the body on the drugs Factors（影响因素）： influencing the processes of pharmacodynamics and pharmacokinetics Drugs Human Body Pharmacodynamics （药效学） Action and mechanism Pharmacokinetics（药动学） Absorption, distribution, metabolism, excretion, and drug concentration in the body Interaction between drug and human body 药物与人体的相互作用 Human Pathogens Drug Interactions between drug , human body, and pathogens 药物、人体和病原体之间的相互作用 Pharmacy 药学 Pharmacology 药理学 Therapeutics 治疗学 Basic Research 基础研究 New Drug 新药研制 Clinical Pharmacology Life Science Screening and Evaluation The Goals of Pharmacology Drugs History Remedies in China and Egypt, recognized and recorded the beneficial and toxic effects of many plant and animal materials. 2500 years ago ～ 17th century. — 本草学 Materia medica, the science of drug preparation and the medical use of drugs: the precursor pharmacology. End of 17th cetury ～ 18th century. —— 药物学 2 History Tradi