尼莫地平治疗血管性非痴呆认知障碍的疗效观察.pdfVIP

www ·zgyS·org 药物与临床 尼莫地平治疗血管性非痴呆认知障碍的疗效观察 杜远敏 (武汉脑科医院神经内科 武汉430010) 摘 要 目的：探讨尼莫地平治疗血管性非痴呆认知障碍的改善作用。方法：76例血管性非痴呆认知障碍患者随机分为A 组39例和B组37例。两组均给予常规治疗(包括阿司匹林片100mg·d～，阿托伐他汀钙20mg·d )，A组在此基础上加用尼 莫地平片30mg，P0，tid。疗程均为12周。治疗前后均运用蒙特利尔认知评分量表(MOCA)评分和简易精神状态评分量表 (MMSE)对临床疗效进行评价 。结果：治疗后，A组MMSE评分、MOCA评分均较治疗前明显提高(P0．05)，且显著高于B 组评分 (P0．05)。B组治疗前后两项评分差异均无统计学意义(P0．05)。A组总有效率明显高于B组 (P0．05)。两组患 者治疗过程中均未出现药品不良反应。结论：尼莫地平对血管性非痴呆认知障碍有防治作用。 关键词 血管性非痴呆认知障碍；尼莫地平；疗效 中图分类号：R972．4 文献标识码 ：A 文章编号：1008-049X(2014)12-2120-03 CurativeEffectofNimodipineonVascularCognitiveImpairmentnoDementia DuYuanmin(DepartmentofNeurology，WuhanBrainHospital，Wuhan430010，China) ABSTRACT Objective：Toinvestigatethecurativeeffectofnimodipineonvascularcognitiveimpairmentnodementia． M ethods：Totally76patientswithvascularcognitiveimpaimr entnodementiawererandomlydividedintogroupA with39cases andgroupBwith37cases．Thetwogroupsweregivenconventionaltreatment(aspirintablets，100mg ·d～，andatorvastatin calcium tablets，20mg ·d～，ThepatientsingroupA weretreatedwithnimodipineadditionally，30mg，po，tid．Thecourseof treatmentofthetwogroupswastwoweeks．TheMontrealCognitiveAssessment(MOCA)andmini-mentalstateexamination (MMSE)wereusedtoevaluatetheefficacyofthetwogroupsbeforeandafterthetreatment．Results：Afterthetreatment，MMSE andMOCAscoresingroupAwereincreasedsignificantlycomparedwiththosebeforethetreatment(P0．05)，andsignificantly higherthanthoseingroupBafterthetreatment(P 0．05)．ThescoresbeforeandafterthetreatmentingroupBshowedno significantdifference(P0．05)．ThetotalefficacyingroupAwasnotablyhigherthanthatingroupB(P0．05)．Nopatient experiencedadversedrugreactionsinboth groups．Conclusion：Nimodipinehaspreventiveandtherapeuticeffectsonvascular cognitiveimpairmentnodementia． ‘ KEY W ORDS Vascularcognitiveimpairmentnodementia；Nimodipine；Efficacy 血管性认知障碍 (vasculardementia，VD)是指由于各种 分 20分，中学及以上文化 24分)；⑤蒙特利尔认知评分 血管因素引起的不同程度的认知障碍类型，产生的以高级神