Hypoxia inducible factor1 Progress.docVIP

 PAGE \* MERGEFORMAT 15 Hypoxia inducible factor1 Progress [Keywords:] Hypoxia inducible factor 1; hypoxia; target gene; Hypertension / Pulmonary Hypoxia inducible factor 1 (hypoxia inducible factor 1, HIF 1) in 1992 and Semenza Wang [1] first discovered, then the structure of established HIF 1, and prove the cDNA coding sequence. HIF 1 commonly found in people and mammalian cells, under normoxic (21% O2) is also expressed, but the synthesis of HIF 1 protein was soon intracellular oxygen-dependent degradation pathway by the ubiquitin-proteasome degradation, and only under hypoxic conditions, HIF 1 in order to stable expression [2]. HIF 1 is a nuclear protein with transcriptional activity, with a wide spectrum of target genes, including one with hypoxia adaptation, inflammation, tumor growth and related development and nearly 100 species of target genes [3,4]. When combined with the target gene by transcriptional and post-transcriptional regulation of the body to produce a series of reactions, although some of the reactions with the compensatory nature of adaptation, but also often brings pathological damage to the body, such as hypoxic pulmonary hypertension (hypoxic pulmonary hypertension, HPH), accelerated tumor growth and so on. 1 HIF 1 the molecular basis of biological activity HIF 1 is a heterodimer mainly by 120kD of HIF 1 @ and 91 ~ 94kD of the two subunits of HIF 1. HIF 1 subunit, also known as aryl hydrocarbon receptor nuclear transporter (aryl hydrocarbon receptor nuclear translocator , ARNT), gene is located on human chromosome 1 q21 area, stable expression in cells, play a structural role; HIF 1 @ gene is located on human chromosome 14 q21 ~ 24 areas, subject to the regulation of hypoxia signal is HIF 1 activity of subunit [5,6]. each subunit contain the amino terminal helix loop helix alkaline (basic helix loop helix, bHLH) conformation and Per / Amt / Sim (PAS) structure, is its heterodimer with the DNA structure necessary for binding.