erk在偏头痛动物模型中激活及与肥大细胞脱颗粒间关系word格式论文.docx

themodelgroupandcontrolgroup,butcontrolgrouphadnosignificantdifferenceatdifferenttimepoint（P0.05）.And therewas obviouslymoreexpressionofp-ERKintheratmodelofmigraineatdifferenttimepointthan controlgroup（P0.05）,Thepositiveunitvaluesofp-ERKatCompound48/80groupatdifferenttimepointwassignificantlyhigherthanthoseintheSCG+Compound48/80groupandexperimentalcontrolgroup（P0.05）.ThegroupofC48/80ismostsignificantat15minthan60minand120min（P0.05）.Conclusion:AftersubcutanceousGTN,theexpressionofp-ERKinthetheduralmaterandtrigeminalnucleuscaudalishadincrease,andchangeswiththenumberofmastcelldegranulation,suggestingthatERKmaybeinvolvedinthesignaltransductionofhyperalgesiainmigraine, mast celldegranulationmaybethereasonofthehighexpressionofp-ERK,andERKsignaltransductionpathwayplaysanimportantroleinthepathogenesisofmigraine.Theexperimentalresultsupporttrigeminovasular.KeyWords:migraine;extracellularsignal-regulatedkinase(p-ERK);mastcell;duralmater;trigeminalnucleuscaudalis;nitroglycerin;rat主要英文缩略语表ACEAngⅠAngiotensinconvertingenzymeAngiotensinⅠ血管紧张素转化酶血管紧张素ⅠAngIIAngiotensinII血管紧张素IIcAMP3-5-cyclicadenosinemonophosphate环磷酸腺苷cGMP3-5-cyclicguanosinemonophosphate环磷酸鸟苷CREBcAMP-responseelementbindingcAMP反应结合蛋白CGRPproteinCalciumgene-relatedpeptide降钙素基因相关多肽C48/80Compound48/80肥大细胞脱颗粒剂CRHCorticotropin-releasing hormone促肾上腺皮质激素释放激素ERKExtracellular signal-egulatedkinase细胞外信号调节激酶p-ERKphosphorylatedextracellular磷酸化细胞外信号调节signal-egulatedkinase激酶GTNNitroglycerin硝酸甘油5-HT5-Hydroxytryptamine5-羟色胺IL-1Interleukin-1白细胞介素-1IL-6Interleukin-6白细胞介素-6ICAM-1intercellularadhesionmolecule-1细胞间黏附因子-1MAPKMitogen-activatedproteinkinase丝裂原活化蛋白激酶MinMinutes分钟NONitricoxide一氧化氮NOSNOsynthase一氧化氮合酶iNOSinduciblenitricoxidesynthase可诱导一氧化氮合酶nNOSneuronsnitricoxide神经元型NONTNeurotensin神经降压素PGProstaglandin前列腺素PGI2ProstaglandinI2前列腺素I2PAR2Proteinase-activatedreceptor2蛋白酶活化受体2SPsubstancePP物质SCGTNF-aTNCSodiumcromoglycateTumornecrosisfactor-alphaTrigeminalnucleuscaudalis色甘酸钠肿瘤坏死因子-α三叉神经核尾侧复合体VEGFvascularendothelialgrowthfactor血管内皮生长因子学位论文